LP437609-3
V gene rearrangement
Active
Description
The gene rearrangement that combines two or three gene segments to form a complete V-region exon generates diversity in two ways. First, there are multiple different copies of each type of gene segment, and different combinations of gene segments can be used in different rearrangement events. This combinatorial diversity is responsible for a substantial part of the diversity of the heavy- and light-chain V regions. Second, junctional diversity is introduced at the joints between the different gene segments as a result of addition and subtraction of nucleotides by the recombination process. A third source of diversity is also combinatorial, arising from the many possible different combinations of heavy- and light-chain V regions that pair to form the antigen-binding site in the immunoglobulin molecule. The two means of generating combinatorial diversity alone could give rise, in theory, to approximately 3.5 × 106 different antibody molecules. Source: NCBI PubMed,
Basic Part Properties
- Part Name
- V gene rearrangement
- Part Display Name
- V gene rearrangement
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2023-11-27
- Construct for LOINC Short Name
- V-region genes
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Reordenamiento de gen V |
| fr-FR | French (France) | V gène réarrangement |
| pl-PL | Polish (Poland) | Rearanżacja genu V Synonyms: Rearanżacja genu regionu V |
| nl-NL | Dutch (Netherlands) | V-genherschikking |
| it-IT | Italian (Italy) | Riarrangiamenti genici V |
| el-GR | Greek (Greece) | Αναδιατάξεις γονιδίων V Synonyms: Αναδιατάξεις γονιδίων V |
| zh-CN | Chinese (China) | V 基因重排 Synonyms: V 基因重排（重组） |
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