LP437610-1

J gene rearrangement

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he joining of a V and a J gene segment creates a continuous exon that encodes the whole of the light-chain V region. In the unrearranged DNA, the V gene segments are located relatively far away from the C region. The J gene segments are located close to the C region, however, and joining of a V segment to a J gene segment also brings the V gene close to a C-region sequence. The J gene segment of the rearranged V region is separated from a C-region sequence only by an intron. In the experiment shown in Fig. 4.1, the germline DNA fragment identified by the 'V-region probe' contains the V gene segment, and that identified by the 'C-region probe' actually contains both the J gene segment and the C-region sequence. To make a complete immunoglobulin light-chain messenger RNA, the V-region exon is joined to the C-region sequence by RNA splicing after transcription , Link

Basic Part Properties

Part Name

J gene rearrangement

Part Display Name

J gene rearrangement

Part Type

Component (Describes the core component or analyte measured)

Created On

2023-11-27

Construct for LOINC Short Name

J gene

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