LP61603-4
Anaplastic lymphoma kinase
Active
Description
Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.
The ALK gene can be oncogenic in two ways - first, by forming a fusion gene with any of several other genes, and second, with mutations of the actual DNA code for the gene itself.
The 2;5 chromosomal translocation is associated with approximately 60% anaplastic large-cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. The product of the NPM-ALK fusion gene is oncogenic.
The EML4-ALK fusion gene is responsible for approximately 3-5% of non-small-cell lung cancer(NSCLC). The vast majority of cases are adenocarcinomas. The standard test used to detect this gene in tumor samples is fluorescence in situ hybridization (FISH), but other techniques such as immunohistochemistry (IHC) and reverse-transcriptase PCR (RT-PCR) can also be used to detect lung cancers with an ALK gene fusion. ALK lung cancers are found in patients of all ages, although on average these patients may be somewhat younger. ALK lung cancers are more common in never or light cigarette smokers, but a significant number of patients with this disease are current or former cigarette smokers.
Recent study shows that mutation of ALK "are linked to 10-15% of "neuroblastoma", a deadly childhood form of cancer.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Wikipedia
Basic Part Properties
- Part Name
- Anaplastic lymphoma kinase
- Part Display Name
- Anaplastic lymphoma kinase
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2006-11-08
- Construct for LOINC Short Name
- ALK
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP61603-4
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 间变型淋巴瘤激酶 Synonyms: ALK 蛋白; |
| es-ES | Spanish (Spain) | Proteína quinasa de linfoma anaplásico |
| it-IT | Italian (Italy) | Linfoma anaplastico chinasi Synonyms: Chinasi del linfoma anaplastico |
| tr-TR | Turkish (Turkey) | Anaplastik lemfoma kinaz |
| ru-RU | Russian (Russian Federation) | Анапластическая лимфомная киназа |
| fr-BE | French (Belgium) | Kinase de lymphome anaplasique |
| fr-CA | French (Canada) | Kinase de lymphome anaplasique |
| nl-NL | Dutch (Netherlands) | anaplastisch lymfoomkinase |
| el-GR | Greek (Greece) | Κινάση αναπλαστικού λυμφώματος Synonyms: Κινάση αναπλαστικού λυμφώματος |
LOINC Copyright
Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://