LP61819-6
Fibroblast growth factor 23.C-terminal
Active
Description
Fibroblast growth factor 23, or FGF23, is primarily produced in bone and helps regulate phosphate and vitamin D metabolism by binding to receptors on renal tubular cells. It is produced as a 251-amino acid precursor consisting of a signal peptide, N-terminal domain, and C-terminal domain. The bioactive form of FGF23 consists of the N- and C-terminal domains after the signal peptide is removed, and is also called the "intact" form. Serine endopeptidase pro-protein convertases cleave the intact form into inactive N-terminal and C-terminal fragments, though the C-terminal fragment may compete with intact FGF23 by binding to renal tubule receptors and thus play a role in regulating overall FGF23 activity. The production of FGF23 is regulated by a variety of factors, including calcium and phosphate levels, 1,25 dihydroxyvitamin D, parathyroid hormone, and iron deficiency. Elevated FGF23 levels are associated with chronic kidney disease as well as cardiovascular disease. PMID: 24269946 Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- Fibroblast growth factor 23.C-terminal
- Part Display Name
- Fibroblast growth factor 23.C-terminal
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2006-12-12
- Construct for LOINC Short Name
- FGF-23 c-term
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 成纤维细胞生长因子.C-末端 Synonyms: FGF-23.C-末端; |
| fr-CA | French (Canada) | Facteur de croissance fibroblaste 23.C-terminal |
| et-EE | Estonian (Estonia) | Fibroblastide kasvufaktor.C-terminaalne |
| es-ES | Spanish (Spain) | Factor de crecimiento fibroblástico 23 (FGF-23) C-terminal |
| it-IT | Italian (Italy) | Fibroblasto, fattore di crescita 23.C-terminale Synonyms: Fattore di crescita del fibroblasto 23.C-terminale |
| tr-TR | Turkish (Turkey) | Fibroblast büyüme faktörü.C-terminal |
| ru-RU | Russian (Russian Federation) | Фибробласт ростовой фактор.C-терминаль Synonyms: Фактор роста фибробластов.C-терминаль |
| nl-NL | Dutch (Netherlands) | fibroblast groeifactor.C-terminaal |
| fr-BE | French (Belgium) | Facteur de croissance fibroblaste.C-terminal |
| fr-FR | French (France) | FGF-23 extrémité C terminale |
| pl-PL | Polish (Poland) | Czynnik wzrostu fibroblastów 23.C-końcowy Synonyms: C-końcowy fragment FGF23 |
| el-GR | Greek (Greece) | Αυξητικός παράγοντας ινοβλαστών 23.C-τερματικό Synonyms: Αυξητικός παράγοντας ινοβλαστών 23.C-τερματικό |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://