LP64437-4
FOXP3
Active
Description
FOXP3 (forkhead box P3) also known as scurfin is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator in the development and function of regulatory T cells.
While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription.
In human disease, alterations in numbers of regulatory T cells - and in particular those that express Foxp3 - are found in a number of disease states. For example, patients with tumors have a local relative excess of Foxp3 positive T cells which inhibits the body's ability to suppress the formation of cancerous cells. Conversely, patients with an autoimmune disease such as systemic lupus erythematosus (SLE) have a relative dysfunction of Foxp3 positive cells. The Foxp3 gene is also mutated in the X-linked IPEX syndrome (Immunodysregulation, Polyendocrinopathy, and Enteropathy, X-linked). These mutations were in the forkhead domain of FOXP3, indicating that the mutations may disrupt critical DNA interactions.
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Source: Wikipedia,
Wikipedia
Basic Part Properties
- Part Name
- FOXP3
- Part Display Name
- FOXP3
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2007-06-18
- Construct for LOINC Short Name
- FOXP3
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | FOXP3 Synonyms: IPEX; |
| fr-CA | French (Canada) | FOXP3 |
| et-EE | Estonian (Estonia) | FOXP3 |
| es-ES | Spanish (Spain) | FOXP3 |
| it-IT | Italian (Italy) | FOXP3 |
| tr-TR | Turkish (Turkey) | FOXP3 |
| ru-RU | Russian (Russian Federation) | FOXP3 |
| nl-NL | Dutch (Netherlands) | FOXP3 |
| fr-BE | French (Belgium) | FOXP3 |
| fr-FR | French (France) | FOXP3 |
| el-GR | Greek (Greece) | FOXP3 Synonyms: FOXP3 |
| pl-PL | Polish (Poland) | FOXP3 Synonyms: Czynnik transkrypcyjny FOXP3 |
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