LP66396-0
Reticulocytes.high light scatter
Active
Description
Reticulocytes are immature red blood cells (RBCs). Measures of reticulocyte maturity can provide complementary information to absolute reticulocyte counts for assessing erythropoietic activity. As reticulocytes mature, they progressively accumulate hemoglobin and lose RNA, so maturity can be measured based on the reticulocyte RNA content. Automated analyzers can use this property to subclassify reticulocytes into different maturity groups by tagging the intracellular RNA and then measuring the light scatter (fluorescence) of the tagged cells, which is proportional to the RNA content. RBCs have the least scatter, followed by the most mature reticulocytes, mid-level, and least mature, which have the highest scatter. The immature reticulocyte fraction (IRF) is defined as the proportion of mid- and high-scatter reticulocytes out of the total. A rise in IRF is one of the earliest indicators of bone marrow engraftment or recovery from intensive chemotherapy. The IRF can also be used as an early indicator of response to erythropoietin therapy in patients with chronic renal failure and to treatment for anemia. (Hematology: Clinical Principles and Applications By Bernadette F. Rodak, George A. Fritsma Kathryn Doig, page 556) Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- Reticulocytes.high light scatter
- Part Display Name
- Reticulocytes.high light scatter
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2007-12-18
- Construct for LOINC Short Name
- HL Retics
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP66396-0
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Reticulocitos.alta dispersión de luz |
| it-IT | Italian (Italy) | Reticolociti.elevata diffusione della luce |
| tr-TR | Turkish (Turkey) | Retikülositler.yüksek ışık saçılımı |
| zh-CN | Chinese (China) | 网织红细胞.高度光散射 Synonyms: 网织红细胞（网状红血球、 |
| ru-RU | Russian (Russian Federation) | Ретикулоциты.высокое света рассеяние |
| nl-NL | Dutch (Netherlands) | reticulocyten.hoge licht scattering |
| pl-PL | Polish (Poland) | Retykulocyty, duże rozpraszanie światła |
| el-GR | Greek (Greece) | Δικτυοερυθροκύτταρα.υψηλή σκέδαση φωτός Synonyms: Δικτυοερυθροκύτταρα.υψηλή σκέδαση φωτός |
LOINC Copyright
Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://