LP68355-4
CD8
Active
Description
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. It is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells. To function, CD8 forms a dimer, consisting of a pair of CD8 chains. The most common form of CD8 is composed of a CD8-α and CD8-β chain, both members of the immunoglobulin superfamily with an immunoglobulin variable (IgV)-like extracellular domain connected to the membrane by a thin stalk, and an intracellular tail. Less-common homodimers of the CD8-α chain are also expressed on some cells. The extracellular IgV-like domain of CD8-α interacts with to the α3 portion of the Class I MHC molecule.[2] This affinity keeps the T cell receptor of the cytotoxic T cell and the target cell bound closely together during antigen-specific activation. Cytotoxic T cells with CD8 surface protein are called CD8+ T cells. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CD8
Basic Part Properties
- Part Name
- CD8
- Part Display Name
- CD8
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2008-04-07
- Construct for LOINC Short Name
- CD8
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | CD8 |
| fr-CA | French (Canada) | CD8 |
| et-EE | Estonian (Estonia) | CD8 |
| es-ES | Spanish (Spain) | CD8 |
| it-IT | Italian (Italy) | CD8 |
| tr-TR | Turkish (Turkey) | CD8 |
| ru-RU | Russian (Russian Federation) | CD8 |
| nl-NL | Dutch (Netherlands) | CD8 |
| fr-BE | French (Belgium) | CD8 |
| fr-FR | French (France) | CD8 |
| pl-PL | Polish (Poland) | CD8 Synonyms: CD8 |
| el-GR | Greek (Greece) | CD8 Synonyms: CD8 |
LOINC Copyright
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