LP68363-8
Alpha synuclein
Active
Description
Alpha-synuclein also known as SNCA is a protein that, in humans, is encoded by the SNCA gene. An alpha-synuclein fragment, known as the non-Abeta component (NAC) of Alzheimer's disease amyloid, originally found in an amyloid-enriched fraction, is shown to be a fragment of its precursor protein, NACP, by cloning of the full-length cDNA. Later, NACP turned out to be a human homologue of Torpedo synuclein. Therefore, NACP is also referred to as human alpha-synuclein.
Normally an unstructured soluble protein, alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. These disorders are known as synucleinopathies. Alpha-synuclein is the primary structural component of Lewy body fibrils. Occasionally, Lewy bodies contain tau protein, however, alpha-synuclein and tau constitute two distinctive subsets of filaments in the same inclusion bodies. Alpha-synuclein pathology is also found in both sporadic and familial cases with Alzheimer's disease.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia,
Wikipedia
Basic Part Properties
- Part Name
- Alpha synuclein
- Part Display Name
- Alpha synuclein
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2008-04-07
- Construct for LOINC Short Name
- a-synuclein
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| et-EE | Estonian (Estonia) | Alfa sünukleiin |
| es-ES | Spanish (Spain) | Alfa-sinucleina |
| it-IT | Italian (Italy) | Alfa sinucleina |
| tr-TR | Turkish (Turkey) | Alfa sinüklein |
| ru-RU | Russian (Russian Federation) | Альфа синуклеин |
| nl-NL | Dutch (Netherlands) | alfa-synucleïne |
| fr-BE | French (Belgium) | Alpha synucléine |
| fr-FR | French (France) | Alpha-synucléine |
| zh-CN | Chinese (China) | Alpha 突触核蛋白 Synonyms: α-突触核蛋白; |
| el-GR | Greek (Greece) | Α-συνουκλεΐνη Synonyms: Α-συνουκλεΐνη |
| pl-PL | Polish (Poland) | Alfa synukleina Synonyms: ASN |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://