LP68374-5

CD33

Active

Description

CD33 is a transmembrane receptor expressed on cells of monocytic/myeloid lineage. It binds sialic acids, therefore is a member of the SIGLEC family of lectins. The extracellular portion of this receptor contains two immunoglobulin domains (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily. The intracellular portion of CD33 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are implicated in inhibition of cellular activity.

CD33 is the target of gemtuzumab ozogamicin, a monoclonal antibody-based treated for acute myeloid leukea. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CD33

Basic Part Properties

Part Name

CD33

Part Display Name

CD33

Part Type

Component (Describes the core component or analyte measured)

Created On

2008-04-07

Construct for LOINC Short Name

CD33

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