LP70434-3
Cycloguanil
Active
Description
Cycloguanil is a dihydrofolate reductase inhibitor, and is a metabolite of the antimalarial drug proguanil; its formation in vivo has been thought to be primarily responsible for the antimalarial activity of proguanil. However, more recent work has indicated that, while proguanil is synergistic with the drug atovaquone (as in the combination Malarone), cycloguanil is in fact antagonistic to the effects of atovaquone, suggesting that, unlike cycloguanil, proguanil may have an alternative mechanism of antimalarial action besides dihydrofolate reductase inhibition.
Although cycloguanil is not currently in general use as an antimalarial, the continuing development of resistance to current antimalarial drugs has led to renewed interest in studying the use of cycloguanil in combination with other drugs
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Source: Wikipedia,
Wikipedia
Basic Part Properties
- Part Name
- Cycloguanil
- Part Display Name
- Cycloguanil
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2008-07-08
- Construct for LOINC Short Name
- Cycloguanil
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| et-EE | Estonian (Estonia) | Tsükloguaniil |
| es-ES | Spanish (Spain) | Cicloguanilo |
| it-IT | Italian (Italy) | Cicloguanile |
| tr-TR | Turkish (Turkey) | Sikloguanil |
| ru-RU | Russian (Russian Federation) | Циклогуанил |
| nl-NL | Dutch (Netherlands) | cycloguanil |
| fr-BE | French (Belgium) | Cycloguanil |
| fr-FR | French (France) | Cycloguanil |
| zh-CN | Chinese (China) | 氯胍三嗪 Synonyms: Cycloguanil; |
| pl-PL | Polish (Poland) | Cykloguanil |
| el-GR | Greek (Greece) | Κυκλογουανίλη Synonyms: Κυκλογουανίλη |
LOINC Copyright
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