LP71023-3
CD11a
Active
Description
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene. ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.
CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.
Efalizumab acts as an immunosuppressant by binding to CD11a.
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Source: Wikipedia
, CD11a
Basic Part Properties
- Part Name
- CD11a
- Part Display Name
- CD11a
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2008-09-16
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| it-IT | Italian (Italy) | CD11a |
| zh-CN | Chinese (China) | CD11a Synonyms: Integrin, alpha L; |
| ru-RU | Russian (Russian Federation) | CD11a |
| es-ES | Spanish (Spain) | CD11a |
| tr-TR | Turkish (Turkey) | CD11a |
| nl-NL | Dutch (Netherlands) | CD11a |
| pl-PL | Polish (Poland) | CD11a Synonyms: CD11a |
| el-GR | Greek (Greece) | CD11a Synonyms: CD11a |
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