Version 2.78

Descriptions

Kynurenine is a metabolite of the amino acid L-tryptophan used in the production of niacin. Kynurenine and its further breakdown products, including 3-hydroxykynurenine and anthranilic acid, carry out diverse biological functions, such as dilating blood vessels during inflammation and regulating the immune response. Some cancers increase kynurenine production, which increases tumor growth. Evidence suggests that increased kynurenine production may precipitate depressive symptoms associated with interferon treatment for hepatitis C. Cognitive deficits in schizophrenia are associated with imbalances in the enzymes that break down kynurenine. Kynurenine production is increased in Alzheimer's disease and cardiovascular disease where its metabolites are associated with cognitive deficits and depressive symptoms. Kynurenine is also associated with tics. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Kynurenine

Kynurenine is a metabolite of the amino acid tryptophan used in the production of niacin. L-kynurenine is a central compound of the pathway of tryptophan metabolism pathway since it can change to the neuroprotective agent kynurenic acid or to the neurotoxic agent quinolinic acid. The break-up of these endogenous compounds' balance can be observable in many disorders. It can occur in neurodegenerative disorders, such as Parkinson's disease, Huntington's and Alzheimer's disease, in stroke, in epilepsy, in multiple sclerosis, in amyotrophic lateral sclerosis, and in mental failures, such as schizophrenia and depression. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Kynurenine, HMDB00684

Basic Part Properties

Part Display Name
Kynurenine
Part Type
Component (Describes the core component or analyte measured)
Created On
2008-09-19

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 3-氨茴酰丙氨酸
Synonyms: 犬尿氨酸原;犬尿氨酸;犬尿酸;犬尿奎林酸
fr-CA French (Canada) Kynurénine
es-ES Spanish (Spain) Quinurenina
it-IT Italian (Italy) Chinurenina
Synonyms: parte ritirata
tr-TR Turkish (Turkey) Kinürenin
nl-NL Dutch (Netherlands) kynurenine
fr-BE French (Belgium) Kynurénine