Version 2.80

Description

The LRRK2 gene (leucine-rich repeat kinase 2) [HGNC Gene ID:18618] is located on chromosome 12q12. This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] [NCBI Gene ID:120892] Source: National Center for Biotechnology Information (NCBI) Gene

Reference Information

Type Source Reference
Webcontent Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. Link to OMIM

Basic Part Properties

Part Name
LRRK2 gene
Part Display Name
LRRK2 gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2008-10-01
Construct for LOINC Short Name
LRRK2 gene

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP71431-8
ConceptMap translate
https://fhir.loinc.org/ConceptMap/$translate?system=http://loinc.org&code=LP71431-8

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gen LRRK2
it-IT Italian (Italy) LRRK2, gene
Synonyms: Gene LRRK2
et-EE Estonian (Estonia) LRRK2 geen
zh-CN Chinese (China) LRRK2 基因
Synonyms: AURA17;DARDARIN;PARK8;RIPK7;ROCO2;Parkinson disease (autosomal dominant) 8;augmented in rheumatoid arthritis 17;leucine-rich repeat kinase 2;帕金森症 (常染色体显性) 8;亮氨酸丰富重复激酶 2;富含亮氨酸重复序列激酶 2;富含亮氨酸重复激酶 2;类风湿关节炎;rheumatoid arthritis;RA
tr-TR Turkish (Turkey) LRRK2 geni
ru-RU Russian (Russian Federation) LRRK2 ген
nl-NL Dutch (Netherlands) LRRK2-gen
Synonyms: LRRK2 gen
el-GR Greek (Greece) Γονίδιο LRRK2
Synonyms: Γονίδιο LRRK2