LP99634-5

ITGB3 gene

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Description

The ITGB3 gene (integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)) [HGNC Gene ID:6156] is located on chromosome 17q21.32. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Decreased expression of CD61 on platelets is associated with Glanzmann thrombasthenia, and CD61 is used as a cell marker in acute megakaryoblastic leukemia (AMKL) [provided by RefSeq, Jul 2008] [NCBI Gene ID:3690] Source: National Center for Biotechnology Information (NCBI) Gene

Reference Information

Type	Source	Reference
Webcontent	Online Mendelian Inheritance in Man^®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.	Link to OMIM

Basic Part Properties

Part Name: ITGB3 gene
Part Display Name: ITGB3 gene
Part Type: Component (Describes the core component or analyte measured)
Created On: 2010-03-08
Construct for LOINC Short Name: ITGB3

Related Codes

Code System	Code	Code Text	Code Version
HUGO Gene Nomenclature Committee (HGNC)	HGNC:6156	ITGB3
National Center for Biotech Info (NCBI) Gene (National Center for Biotechnology Information (NCBI) Gene)	3690	ITGB3

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Language Variants Get Info

Tag	Language	Translation
zh-CN	Chinese (China)	ITGB3 基因 Synonyms: CD61;GP3A;GPIIIa;integrin beta chain, beta 3;platelet glycoprotein IIIa;integrin, beta 3;整合素 beta 链, beta 3;血小板糖蛋白 IIIa;整合素, beta 3;整合蛋白 beta 链, beta 3;整合蛋白, beta 3;整合素β链, β3;血小板糖蛋白 IIIa;整合素, β3;整合蛋白β链, β3;整合蛋白, β3
et-EE	Estonian (Estonia)	ITGB3 geen
es-ES	Spanish (Spain)	Gen ITGB3
it-IT	Italian (Italy)	ITGB3, gene Synonyms: Gene ITGB3
tr-TR	Turkish (Turkey)	ITGB3 geni
ru-RU	Russian (Russian Federation)	ITGB3 ген
nl-NL	Dutch (Netherlands)	ITGB3-gen Synonyms: ITGB3 gen
fr-FR	French (France)	ITGB3 gène
pl-PL	Polish (Poland)	ITGB3 gen Synonyms: Gen ITGB3
el-GR	Greek (Greece)	Γονίδιο ITGB3 Synonyms: Γονίδιο ITGB3

LOINC Copyright

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