LP99635-2
FGB gene
Active
Description
The FGB gene (fibrinogen beta chain) [HGNC Gene ID:3662] is located on chromosome 4q28. The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] [NCBI Gene ID:2244] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Name
- FGB gene
- Part Display Name
- FGB gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2010-03-08
- Construct for LOINC Short Name
- FGB
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | FGB 基因 Synonyms: MGC104327; |
| et-EE | Estonian (Estonia) | FGB geen |
| es-ES | Spanish (Spain) | Gen FGB |
| it-IT | Italian (Italy) | FGB, gene Synonyms: Gene FGB |
| tr-TR | Turkish (Turkey) | FGB geni |
| ru-RU | Russian (Russian Federation) | FGB ген |
| nl-NL | Dutch (Netherlands) | FGB-gen Synonyms: FGB gen |
| fr-FR | French (France) | FGB gène |
| pl-PL | Polish (Poland) | FGB gen Synonyms: Gen FGB |
| el-GR | Greek (Greece) | Γονίδιο FGB Synonyms: Γονίδιο FGB |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://