Fluorquinolones are among most beneficial drugs used to treat multi-drug resistant Mycobacterium tuberculosis (MDR-TB) infections. The fluorquinolones affect the activity of DNA gyrase by reducing the cell's ability for DNA replication and transcription. DNA gyrase in Mycobacterium tuberculosis (TB) is made of two subunits that are encoded by gyrA and gyrB. Mutations in the gyrA quinolone resistance-determining region (QRDR) are responsible for causing most of the drug resistance of TB to the fluoroquinolones. The gyrB mutations have a much smaller impact on TB resistance to the fluoroquinolones.[PMID: 26763957] Source: Regenstrief LOINC
- Short Name
- FLQ Susc Islt
- Display Name
- Fluoroquinolone [Susc]
- Consumer Name Alpha
- Susceptibility to Fluoroquinolone
Example Answer List: LL360-9Source: Regenstrief Institute
|PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
- First Released
- Version 2.72
- Last Updated
- Version 2.72
- Order vs. Observation
Member of these Groups
|LOINC Group||Group Name|
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