101662-5

Abnormal Prion Protein [Presence] in Cerebrospinal Fluid by RT-QuIC

Active

Term Description

Detection of pathologic prions in cerebrospinal fluid (CSF). The test uses recombinant prion protein (PrP) as a reagent substrate and patient CSF in a real-time quaking-induced conversion (RT-QuIC) assay. If pathologic prions are present in the patient's CSF, they propagate misfolding of the reagent PrP to form amyloid, which is detected using a fluorescent indicator. RT-QuIC has been adopted in clinical practice due to the sensitivity, specificity, and use of CSF (not a brain biopsy) for testing. The reported sensitivity of RT-QuIC in detecting CJD is >90%, and the specificity approaches 100%.

Part Descriptions

LP35078-2 Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Transmissible spongiform encephalopathy

LP435248-2 RT-QuIC
Real-time quaking-induced conversion (RT-QuIC) a technique to detect small amounts of PrPSc.. RT-QuIC test manipulates the ability of PrPSc to induce PrPC to misfold in a cyclical fashion to form aggregates of PrPSc fibrils, in real time by binding to a fluorescent dye, namely thioflavin T. Source: LOINC

LOINC Names Get Info

Fully-Specified Name: Prion protein.abnormal:PrThr:Pt:CSF:Ord:RT-QuIC
Long Common Name: Abnormal Prion Protein [Presence] in Cerebrospinal Fluid by RT-QuIC
Short Name: Abn Prion Prot CSF Ql RT-QuIC
Display Name: Abnormal Prion Protein RT-QuIC Ql (CSF)
Consumer Name Alpha Get Info: Abnormal prion protein, Spinal fluid

Part Model Get Info

Component
Prion protein.abnormal
LP35078-2
- Analyte
  Prion protein.abnormal
  LP35078-2
  - Component Numerator
    Prion protein.abnormal
    LP35078-2
    - Component Numerator Core
      Prion protein.abnormal
      LP35078-2
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
CSF
LP7156-5
- System Core
  CSF
  LP7156-5
- Super System
  NULL
Scale
Ord
LP7751-3
Method
RT-QuIC
LP435248-2

Example Answer List: LL2038-9

Source: Quest Diagnostics Inc.

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value)			LA11884-6

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.75
Last Updated: Version 2.83 (MIN)
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
104134-2	Dementia evaluation panel - Cerebrospinal Fluid

Language Variants Get Info

Tag	Language	Translation
ar-JO	Arabic (Jordan)	الكشف عن تواجد البروتين البريوني الغير طبيعي في السائل الدماغي الشوكي ( بتقنية
cs-CZ	Czech (Czechia)	Prionový protein abnormální:Přítomnost nebo práh:Časový bod:Mozkomíšní mok:Ordinální:Test RT-QuIC
el-GR	Greek (Greece)	Πρωτεΐνη πριόν.μη φυσιολογική:PrThr:Pt:ΕΝΥ:Ord:RT-QuIC Synonyms: CHEM Ord PrThr Pt RT-QuIC ΕΝΥ Πρωτεΐνη Πρωτεΐνη πριόν.μη φυσιολογική
es-ES	Spanish (Spain)	Proteína priónica anormal:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:RT-QUIC Synonyms: Ensayo de conversión de proteína priónica inducida por agitación en tiempo real
fr-FR	French (France)	Protéine prion anormale:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:RT-QuIC
it-IT	Italian (Italy)	Proteina prionica.anormale:PrThr:Pt:LCS:Ord:RT-QuIC Synonyms: Chimica Liquido cerebrospinale Presenza o Soglia Proteina Prionica Anormale Punto nel tempo (episodio) Real Time Quaking Induced Conversion
nl-NL	Dutch (Netherlands)	prioneiwit.abnormaal:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:RT-QulC Synonyms: real-time quaking-induced conversion
zh-CN	Chinese (China)	朊病毒蛋白.异常:存在情况或阈值:时间点:脑脊液:序数型:RT-QuIC Synonyms: BSE;Scrapie;亲染子蛋白.异常;异常亲染子蛋白;异常感染性蛋白质;异常朊病毒蛋白;异常蛋白感染素;感染性蛋白质.异常;牛海绵状脑病;牛海绵状脑病（Bovine spongiform encephalopathy，BSE）;疯牛病;羊痒病;羊瘙痒病;羊瘙痒病（Scrapie）;蛋白感染素.异常 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质不平常的不正常的亲染子蛋白依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类反常的存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）实时震荡诱导转化异常的感染性蛋白质时刻;随机;随意;瞬间脊液脊髓液脑脊液（Cerebral spinal fluid，CSF）脑脊髓液蛋白感染素非一般的非惯例的

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=101662-5

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.