Version 2.78

Term Description

Identifying monoclonal gammopathies using 24H urine specimens.
Source: Regenstrief LOINC

Part Descriptions

LP186074-3   MS.MALDI-TOF
Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) is a type of mass spectrometry (MS). MALDI-TOF MS consists of three primary steps: 1) mixing the sample with an organic matrix, which provides a scaffolding and also protons for the ionization process; 2) applying a laser to the matrix, which absorbs energy from the laser and releases it into the sample, which causes the sample to desorb and form singly charged ions; and 3) using a flight tube to analyze the mass of the ions, ultimately resulting in a mass spectrum in which the mass-to-charge is plotted against signal intensity. MALDI-TOF is a soft ionization technique, meaning that molecules remain relatively intact during ionization. Because of this property, MALDI-TOF can be used for protein analysis; in contrast, older MS techniques cause extensive protein fragmentation and therefore cannot be used for this purpose. One application of MALDI-TOF is in clinical microbiology; compared to traditional methods, MALDI-TOF is faster and more accurate in identifying specific microorganisms. PMID: 23824373 Source: Regenstrief LOINC, PMID: 23824373

LP30793-1   Protein.monoclonal
A monoclonal band (M-spike, monoclonal protein isotype) is often found in patients with monoclonal gammopathies. Following protein electrophoresis, immunofixation is used to identify the immunoglobulin heavy chain and/or light chain. Monoclonal peaks greater than 3 g/dL and IgG or IgA are seen in patients with Multiple Myeloma (MM). A monoclonal peak greater than 3 g/dL and IgM is seen in patients with macroglobulinemia. An alternate methodology for identifying the monoclonal protein isotype is MALDI-TOF, in which known information regarding the unique mass of each isotype is used to determine and quantify the isotype present in the patient sample based on the mass spectra generated from the sample. Source: Regenstrief LOINC

Fully-Specified Name

Component
Protein.monoclonal
Property
PrThr
Time
24H
System
Urine
Scale
Ord
Method
MS.MALDI-TOF

Additional Names

Short Name
M Protein 24h Ur Ql MS.MALDI-TOF
Display Name
Protein.monoclonal MS.MALDI-TOF Ql (24H U)
Consumer Name Alpha Get Info
Protein.monoclonal, Urine

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.75
Last Updated
Version 2.75
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
101665-8 Protein electrophoresis and M protein isotype panel - 24 hour Urine

Member of these Groups Get Info

LOINC Group Group Name
LG51452-7 Protein.monoclonal|PrThr|Urine

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Proteinas monoclonales:PrThr:24 horas:Orina:Ord:MS.MALDI-TOF
fr-FR French (France) Immunoglobuline monoclonale:Présence/Seuil:24H:Urine:Qualitatif:Spectrométrie MALDI-TOF
it-IT Italian (Italy) Proteina.monoclonale:PrThr:24h:Urine:Ord:MS.MALDI-TOF
Synonyms: 24 Ore Chimica Presenza o Soglia
nl-NL Dutch (Netherlands) eiwit.monoclonale:aanwezigheid:24 uur:urine:ordinaal:MALDI-TOF
Synonyms: 24U massaspectometrie; Malditof
pl-PL Polish (Poland) Białko monoklonalne:granica wykrywalności:24 godziny:mocz:półilościowy:spektrometria mas.MALDI-TOF
zh-CN Chinese (China) 蛋白质.单克隆型:存在情况或阈值:24小时:尿液:序数型:MS.MALDI-TOF
Synonyms: 1天;1日;24.0小时;一天;一日;二十四个小时;二十四小时 M 区带;M 峰;M 带;M 蛋白;副蛋白;单克隆区带;单克隆型蛋白质;单克隆型蛋白质区带;单克隆峰;单克隆性蛋白质;单克隆性蛋白质区带;单克隆蛋白质区带;异常蛋白;病变蛋白;蛋白质.单克隆 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 基质辅助激光解吸/电离飞行时间质谱;基质辅助激光解吸电离飞行时间质谱;基质辅助激光解吸飞行时间质谱;基质辅助激光解析电离飞行时间质谱;Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry;MALDI-TOF-MS;Matrix-assisted laser desorption ionization-time of flight 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 尿;小便;下泉

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=101667-4