101670-8
Protein.monoclonal [Presence] in Urine by MS.MALDI-TOF
Active
Term Description
Identifying monoclonal gammopathies using random urine specimens.
Source: Regenstrief LOINC
Part Descriptions
LP186074-3 MS.MALDI-TOF
Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) is a type of mass spectrometry (MS). MALDI-TOF MS consists of three primary steps: 1) mixing the sample with an organic matrix, which provides a scaffolding and also protons for the ionization process; 2) applying a laser to the matrix, which absorbs energy from the laser and releases it into the sample, which causes the sample to desorb and form singly charged ions; and 3) using a flight tube to analyze the mass of the ions, ultimately resulting in a mass spectrum in which the mass-to-charge is plotted against signal intensity. MALDI-TOF is a soft ionization technique, meaning that molecules remain relatively intact during ionization. Because of this property, MALDI-TOF can be used for protein analysis; in contrast, older MS techniques cause extensive protein fragmentation and therefore cannot be used for this purpose. One application of MALDI-TOF is in clinical microbiology; compared to traditional methods, MALDI-TOF is faster and more accurate in identifying specific microorganisms. PMID: 23824373
Source: Regenstrief LOINC, PMID: 23824373
LP30793-1 Protein.monoclonal
A monoclonal band (M-spike, monoclonal protein isotype) is often found in patients with monoclonal gammopathies. Following protein electrophoresis, immunofixation is used to identify the immunoglobulin heavy chain and/or light chain. Monoclonal peaks greater than 3 g/dL and IgG or IgA are seen in patients with Multiple Myeloma (MM). A monoclonal peak greater than 3 g/dL and IgM is seen in patients with macroglobulinemia. An alternate methodology for identifying the monoclonal protein isotype is MALDI-TOF, in which known information regarding the unique mass of each isotype is used to determine and quantify the isotype present in the patient sample based on the mass spectra generated from the sample.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Protein.monoclonal
- Property
- PrThr
- Time
- Pt
- System
- Urine
- Scale
- Ord
- Method
- MS.MALDI-TOF
Additional Names
- Short Name
- M Protein Ur Ql MS.MALDI-TOF
- Display Name
- Protein.monoclonal MS.MALDI-TOF Ql (U)
- Consumer Name Alpha Get Info
- Protein.monoclonal, Urine
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.75
- Last Updated
- Version 2.75
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 101668-2 | Protein electrophoresis and M protein isotype panel - Urine |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG51452-7 | Protein.monoclonal| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Proteinas monoclonales: |
| fr-FR | French (France) | Immunoglobuline monoclonale: |
| it-IT | Italian (Italy) | Proteina.monoclonale: Synonyms: Chimica Presenza o Soglia Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | eiwit.monoclonale: Synonyms: massaspectometrie; |
| pl-PL | Polish (Poland) | Białko monoklonalne: |
| zh-CN | Chinese (China) | 蛋白质.单克隆型: Synonyms: M 区带; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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LOINC Copyright
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