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Part Description

LP220363-8   3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase (HMG-CoA reductase or HMGCR) is an enzyme in the cholesterol-synthesis pathway and is the target of HMG-CoA reductase inhibitors, also known as statins. Autoantibodies to HMGCR may be a marker of necrotizing autoimmune myopathy (NAM), which is characterized by muscle fiber necrosis with little or no inflammation and responsiveness to immunosuppressive treatment. Anti-HMGCR positive cases of NAM usually have limited extramuscular involvement, slow onset of muscle disease, and can occur in both adults and children. Due to the insidious onset, pediatric cases of NAM may be initially confused with muscular dystrophy. The anti-HMGCR antibody titer may correlate with muscle strength and creatine kinase level. Some cases of NAM have been diagnosed in patients previously exposed to statins, and in some of these cases, stopping the statin drug was the only intervention necessary for the resolution of disease. However, exposure to statins is not required to diagnose cases of NAM, and first-line treatment typically includes corticosteroids or other immunosuppressive drugs such as methotrexate. PMID: 24797170 Source: Regenstrief LOINC, PMID: 24797170

LOINC Names Get Info

Fully-Specified Name
3-Hydroxy-3-Methylglutaryl-Coenzyme A reductase Ab:RelACnc:Pt:Ser:Qn:IA
Long Common Name
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab in Serum by Immunoassay
Short Name
HMGCR Ab Ser IA
Display Name
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab IA (S) [Rel units/Vol]
Consumer Name Alpha Get Info
3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase antibody, Blood

Part Model Get Info

  • Component
    3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab
    LP220363-8
    • Analyte
      3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab
      LP220363-8
      • Component Numerator
        3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab
        LP220363-8
        • Component Numerator Core
          3-Hydroxy-3-Methylglutaryl-coenzyme A reductase
          LP220364-6
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    RelACnc
    LP35077-4
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    IA
    LP217197-5

Example Answer List: LL744-4

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
DetectedLA11882-0
Not detectedLA11883-8

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.75
Last Updated
Version 2.75 (ADD)
Order vs. Observation
Observation

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)3-hydroxy-3-methylglutaryl-koenzym A reduktáza Ab:Relativní arbitrární koncentrace:Časový bod:Sérum:Kvantitativní:Imunoanalýza
el-GRGreek (Greece)Αναγωγάση του 3-υδροξυ-3-μεθυλογλουταρυλο-συνενζύμου Α Αντίσωμα:RelACnc:Pt:Ορός:Qn:IA
Synonyms: A IA Pt Qn RelACnc SERO Αναγωγάση του 3-υδροξυ-3-μεθυλογλουταρυλο-συνενζύμου Α Αντίσωμα Ορός
es-ESSpanish (Spain)3-Hidroxy-3-metilglutaril-CoA reductasa Anticuerpos:Concentración arbitraria relativa:Punto temporal:Suero:Qn:IA
Synonyms: Cuantitativo
fr-FRFrench (France)3-hydroxy-3-méthyglutaryl-coenzyme A réductase Ac:Activité arbitraire relative:Ponctuel:Sérum:Numérique:Immunoanalyse
it-ITItalian (Italy)3-idrossi-3-metilglutaril-coenzima A reduttasi Ab:RelACnc:Pt:Siero:Qn:IA
Synonyms: anticorpo Concentrazine Arbitraria Relativa Immunoassay Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)3-hydroxy-3-methylglutaryl-CoA-reductase As:relatieve eenheid/volume:moment:serum:kwantitatief:immunoassay
Synonyms: antistof; antilichaam IA
pl-PLPolish (Poland)Reduktaza 3-hydroksy-3-metyloglutarylo-koenzymu A Ab:względne stężenie umowne:punkt w czasie:surowica:ilościowy:metoda immunologiczna
Synonyms: Reduktaza HMG-CoA
zh-CNChinese (China)3-羟基-3-甲基戊二酰-辅酶 A 还原酶 抗体:相对任意型浓度:时间点:血清:定量型:免疫测定法
Synonyms: 3-羟基-3-甲基戊二酰基-辅酶 A 还原酶;3-羟基-3-甲基戊二酰基辅酶 A 还原酶;3-羟基-3-甲基戊二酰辅酶 A 还原酶;3-羟基-3-甲基戊二酰-CoA 还原酶;3-羟基-3-甲基戊二酰基-CoA 还原酶;3-羟基-3-甲基戊二酰基 CoA 还原酶;3-羟基-3-甲基戊二酰 CoA 还原酶 Ⅲ A 型 Ab;自身抗体 Hydroxy III OH 三 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 叁 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 相对任意浓度;相对型任意浓度;相对人工型浓度 羟 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

UnitSource
%Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=101740-9