102036-1
Abnormal Prion Protein [Interpretation] in Cerebrospinal Fluid Document by RT-QuIC
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Term Description
Transmissible spongiform encephalopathies (TSEs or prion diseases) are a rare group of invariably fatal neurodegenerative disorders that affect humans and other mammals. TSEs are protein misfolding diseases that involve the accumulation of an abnormally aggregated form of the normal host prion protein (PrP). They are unique among protein misfolding disorders in that they are transmissible and have different strains of infectious agents that are associated with unique phenotypes in vivo. https://pubmed.ncbi.nlm.nih.gov/19157856/#:~:text=Abstract,host%20prion%20protein%20(PrP).
Part Descriptions
LP35078-2 Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms.
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Source: Wikipedia,
Transmissible spongiform encephalopathy
LP435248-2 RT-QuIC
Real-time quaking-induced conversion (RT-QuIC) a technique to detect small amounts of PrPSc.. RT-QuIC test manipulates the ability of PrPSc to induce PrPC to misfold in a cyclical fashion to form aggregates of PrPSc fibrils, in real time by binding to a fluorescent dye, namely thioflavin T.
Source: LOINC
LOINC Names Get Info
- Fully-Specified Name
- Prion protein.abnormal:
Imp: Pt: CSF: Doc: RT-QuIC - Long Common Name
- Abnormal Prion Protein [Interpretation] in Cerebrospinal Fluid Document by RT-QuIC
- Short Name
- Abn Prion Prot CSF Doc RT-QuIC-Imp
- Display Name
- Abnormal Prion Protein RT-QuIC Doc (CSF) [Interp]
- Consumer Name Alpha Get Info
- Abnormal prion protein, Spinal fluid
Part Model Get Info
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.75
- Last Updated
- Version 2.83 (MIN)
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Prionový protein abnormální: |
| el-GR | Greek (Greece) | Πρωτεΐνη πριόν.μη φυσιολογική: Synonyms: Doc Imp MICRO Pt RT-QuIC ΕΝΥ Πρωτεΐνη Πρωτεΐνη πριόν.μη φυσιολογική |
| es-ES | Spanish (Spain) | Proteína priónica anormal: Synonyms: Ensayo de conversión de proteína priónica inducida por agitación en tiempo real |
| fr-FR | French (France) | Protéine prion anormale: |
| it-IT | Italian (Italy) | Proteina prionica.anormale: Synonyms: Impressione/interpretazione di studio Liquido cerebrospinale Microbiologia Proteina Prionica Anormale Punto nel tempo (episodio) Real Time Quaking Induced Conversion |
| nl-NL | Dutch (Netherlands) | prioneiwit.abnormaal: Synonyms: real-time quaking-induced conversion |
| zh-CN | Chinese (China) | 朊病毒蛋白.异常: Synonyms: BSE; |
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