Version 2.77

Term Description

To date, the gold standard method to evaluate the GCN of MET is fluorescence in situ hybridization (FISH). However, next-generation sequencing (NGS) is becoming more relevant to optimize therapy by revealing the mutational profile of each NSCLC. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508248/]
Source: Regenstrief LOINC

Part Description

LP269809-2   MET gene amplification
MET gene amplification studies evaluate the number of copies of the MET gene present in a single cell. Amplification is determined based on the MET gene copy number and MET to centromere ratio. Different criteria have been proposed for what constitutes amplification, including a MET to centromere ratio of >= 2, an average MET gene copy number >=5, and at least 15 gene copies in 10% of the tumor cell nuclei that were counted. MET amplification is associated with worse prognosis in a variety of cancers, including non-small cell lung and gastroesophageal cancer. PMID: 27926778 Source: Regenstrief LOINC

Fully-Specified Name

Component
MET gene amplification
Property
Find
Time
Pt
System
Bld/Tiss
Scale
Doc
Method
Molgen

Additional Names

Short Name
MET gene amplification Bld/T Molgen
Display Name
MET amplification Molgen Doc (Bld/Tiss)
Consumer Name Alpha Get Info
MET amplification, Blood or tissue specimen

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.75
Last Updated
Version 2.75
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Amplificación del gen MET:Hallazgo:Punto temporal:Sangre o tejido:Doc:Genética molecular
it-IT Italian (Italy) Gene MET, amplificazione:Osservazione:Pt:Sangue/Tess:Doc:Molgen
Synonyms: Amplificazione gene MET Gene MET Genetica molecolare Osservazione Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) MET-genamplificatie:bevinding:moment:bloed of weefsel:document:moleculair genetisch onderzoek
Synonyms: molgen
zh-CN Chinese (China) MET 基因扩增:发现:时间点:全血/组织:文档型:分子遗传学类实验室方法
Synonyms: MET 原癌基因;受体酪氨酸激酶 Met;肝细胞生长因子受体;hepatocyte growth factor receptor;MET;MET proto-oncogene;receptor tyrosine kinase Met;AUTS9;HGFR;RCCP2;c-Met;DFNB97;OSFD 临床文档型;临床文档;文档;文书;医疗文书;临床医疗文书 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内,用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 发现是一个原子型临床观察指标,并不是作为印象的概括陈述。体格检查、病史、系统检查及其他此类观察指标的属性均为发现。它们的标尺对于编码型发现可能是名义型,而对于叙述型文本之中所报告的发现,则可能是叙述型。;发现物;所见;结果;结论 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=102039-5