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Term Description

To date, the gold standard method to evaluate the GCN of MET is fluorescence in situ hybridization (FISH). However, next-generation sequencing (NGS) is becoming more relevant to optimize therapy by revealing the mutational profile of each NSCLC. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508248/

Part Description

LP269809-2   MET gene amplification
MET gene amplification studies evaluate the number of copies of the MET gene present in a single cell. Amplification is determined based on the MET gene copy number and MET to centromere ratio. Different criteria have been proposed for what constitutes amplification, including a MET to centromere ratio of >= 2, an average MET gene copy number >=5, and at least 15 gene copies in 10% of the tumor cell nuclei that were counted. MET amplification is associated with worse prognosis in a variety of cancers, including non-small cell lung and gastroesophageal cancer. PMID: 27926778 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
MET gene amplification:Find:Pt:Bld/Tiss:Doc:Molgen
Long Common Name
MET gene amplification in Blood or Tissue by Molgen
Short Name
MET gene amplification Bld/T Molgen
Display Name
MET amplification Molgen Doc (Bld/Tiss)
Consumer Name Alpha Get Info
MET amplification, Blood or tissue specimen

Part Model Get Info

  • Component
    MET gene amplification
    LP269809-2
    • Analyte
      MET gene amplification
      LP269809-2
      • Component Numerator
        MET gene amplification
        LP269809-2
        • Component Numerator Core
          MET gene amplification
          LP269809-2
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Find
    LP6813-2
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Doc
    LP32888-7
  • Method
    Molgen
    LP6404-0

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.75
Last Updated
Version 2.75 (ADD)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Gen MET amplifikace:Nález:Časový bod:Krev/tkáň:Dokument:Molekulární genetika
el-GRGreek (Greece)Ενίσχυση του γονιδίου MET:Εύρεση:Pt:Αίμα/Ιστός:Doc:Μοριακή γενετική
Synonyms: Doc MOLPATH Pt Αίμα Αίμα/Ιστός Γονίδιο Γονίδιο MET Ενίσχυση του γονιδίου MET Εύρεση Ιστός Μοριακή γενετική
es-ESSpanish (Spain)Amplificación del gen MET:Hallazgo:Punto temporal:Sangre o tejido:Doc:Genética molecular
fr-FRFrench (France)MET gène amplification:Recherche:Ponctuel:Sang/Tissu:Document:Biologie moléculaire
it-ITItalian (Italy)Gene MET, amplificazione:Osservazione:Pt:Sangue/Tess:Doc:Molgen
Synonyms: Amplificazione gene MET Gene MET Genetica molecolare Osservazione Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NLDutch (Netherlands)MET-genamplificatie:bevinding:moment:bloed of weefsel:document:moleculair genetisch onderzoek
Synonyms: molgen
pl-PLPolish (Poland)Amplifikacja genu MET:stwierdzenie:punkt w czasie:krew lub tkanka:dokument:genetyka molekularna
Synonyms: diagnostyka molekularna Gen MET
zh-CNChinese (China)MET 基因扩增:发现:时间点:全血/组织:文档型:分子遗传学类实验室方法
Synonyms: MET 原癌基因;受体酪氨酸激酶 Met;肝细胞生长因子受体;hepatocyte growth factor receptor;MET;MET proto-oncogene;receptor tyrosine kinase Met;AUTS9;HGFR;RCCP2;c-Met;DFNB97;OSFD 临床文档型;临床文档;文档;文书;医疗文书;临床医疗文书 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 发现是一个原子型临床观察指标，并不是作为印象的概括陈述。体格检查、病史、系统检查及其他此类观察指标的属性均为发现。它们的标尺对于编码型发现可能是名义型，而对于叙述型文本之中所报告的发现，则可能是叙述型。;发现物;所见;结果;结论 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=102039-5