LOINC
Version 2.72

10484-4Glial fibrillary acidic protein Ag [Presence] in Tissue by Immune stainActive

Part Descriptions

LP38247-0   Glial fibrillary acidic protein Ag
Glial fibrillary acidic protein (GFAP) is a protein that in humans is encoded by the GFAP gene.

Glial fibrillary acidic protein is an intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes, and ependymal cells. GFAP has also been found to be expressed in glomeruli and peritubular fibroblasts taken from humans, human keratinocytes, human osteocytes and chondrocytes. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cells but its exact function remains poorly understood, despite the number of studies using it as a cell marker.

There are multiple disorders associated with improper GFAP regulation, and injury can cause glial cells to react in detrimental ways. Glial scarring is a consequence of several neurodegenerative conditions, as well as injury that severs neural material. The scar is formed by astrocytes interacting with fibrous tissue to re-establish the glial margins around the central injury core and is partially caused by up-regulation of GFAP.

Another condition directly related to GFAP is Alexander disease, a rare genetic disorder. Its symptoms include mental and physical retardation, dementia, enlargement of the brain and head, spasticity (stiffness of arms and/or legs), and seizures. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP14666-9   Glial fibrillary acidic protein
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein highly expressed in the central nervous system (CNS), almost exclusively in astrocytes, as well as in the peripheral nervous system (PNS). GFAP is used as a biomarker for traumatic brain injuries (TBIs) and stroke. In the presence of astrogliosis, GFAP gene activation and protein production are found to be increased. Additionally, studies have found that an increased amount of GFAP is found in serum following TBIs and stroke.[PMID:25975510] Source: Regenstrief LOINC

Fully-Specified Name

Component
Glial fibrillary acidic protein Ag
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Immune stain

Additional Names

Short Name
GFAP Ag Tiss Ql ImStn
Display Name
Glial fibrillary acidic protein Ag Immune stain Ql (Tiss)
Consumer Name Alpha
Glial fibrillary acidic protein antigen, Tissue

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 1.0i
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (China)
神经胶质纤维酸性蛋白 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
nl-NLDutch (Netherlands)
gliaal fibrillair acidisch proteïne Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
et-EEEstonian (Estonia)
Gliia fibrillaarne happeline valk antigeen:PrThr:Pt:Tis:Ord:Immuunvärv
fr-BEFrench (Belgium)
Protéine acide fibrillaire gliale Ag:PrThr:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
fr-CAFrench (Canada)
Protéine acide fibrillaire gliale , Ag:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
fr-FRFrench (France)
GFAP antigène:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
it-ITItalian (Italy)
Proteina acida fibrillare gliale , Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
ko-KRKorean (Korea, Republic of)
신경 교원섬유 산 단백 항원:임의농도:검사시점:조직:순위척도:면역염색
pt-BRPortuguese (Brazil)
Proteína glial fibrilar ácida Ag:ACnc:Pt:Tecido:Ord:Imunocoloração
ru-RURussian (Russian Federation)
Глиальный фибриллярный кислый протеин Аг:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска
es-ARSpanish (Argentina)
[antígeno de] proteína acídica fibrilar de la glía [Ag]:concentración arbitraria:punto en el tiempo:tejido, no especificado:ordinal:tinción inmunológica
es-MXSpanish (Mexico)
Proteína ácida fibrilar glial Ag:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
es-ESSpanish (Spain)
Proteina ácida fibrilar glial Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
tr-TRTurkish (Turkey)
Glial fibriler asidik protein Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=10484-4