104992-3
Paraneoplastic vision loss evaluation panel - Serum
Active
83003-4 Recoverin IgG Ab [Presence] in Serum or Plasma by Line blot
Term Description
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC
Part Descriptions
LP222259-6 Recoverin
Recoverin is a calcium-binding photoreceptor protein that has been identified as the target of autoantibodies that results in cancer-associated retinopathy (CAR). CAR is a paraneoplastic syndrome where autoantibodies against an unknown neoplasm cross-react with retinal photoreceptor antigens and damage them leading to vision loss. PMID: 7568096 Only 65% of patients with CAR have detectable antiretinal antibodies and antibodies specific to recoverin are found in approximately 10% of those patients. Most tumors associated with CAR include small-cell lung cancer and gynecological malignancies. Neoplasms that are less often associated with CAR include bladder, prostate, pancreatic, small bowel, thymus, thyroid and colon. PMID: 26862417 Recoverin antibodies lead to cancer-associated retinopathy and have been shown to induce apoptotic death to photoreceptor cells. PMID: 12417436
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Recoverin Ab.IgG
- Property
- PrThr
- Time
- Pt
- System
- Ser/Plas
- Scale
- Ord
- Method
- Line blot
Additional Names
- Short Name
- Recoverin IgG SerPl Ql Line blot
- Display Name
- Recoverin IgG Line blot Ql
- Consumer Name Alpha Get Info
- Recoverin IgG antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.66
- Change Reason
- This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
- Order vs. Observation
- Both
Example Answer List LL360-9
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 104992-3 | Paraneoplastic vision loss evaluation panel - Serum |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Recuperación Ab.IgG: |
| es-ES | Spanish (Spain) | Recoverina IgG: |
| fr-FR | French (France) | Recovérine anticorps IgG: |
| it-IT | Italian (Italy) | Recoverin Ab.IgG: Synonyms: anticorpi IgG anticorpo Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | recoverine As.IgG: Synonyms: antistof; |
| zh-CN | Chinese (China) | 恢复蛋白 抗体.IgG: Synonyms: Ab.IgG; |
Third Party Copyright
This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.
This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.
Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.
72504-4 CV2 Ab [Presence] in Serum or Plasma by Immunofluorescence
Part Descriptions
LP32718-6 CV2
CV2 (CRMP5) antibody binds to cytoplasm and cell processes of a subpopulation of oligodendrocytes in the white matter and targets 66 kDa protein known as CRMP5.
It is ofen found in association with small cell lung carcinoma. CV2 autoimmune response can also be found in cerebellar ataxia, encephalomyelitis, limbic encephalitis, sensory and sensorimotor neuropathy, autonomic neuropathy, and chorea. CV2 autoantibodies are also present in patients with rapidly progressive dementia, and are used to monitor treatment in some cases.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- CV2 Ab
- Property
- PrThr
- Time
- Pt
- System
- Ser/Plas
- Scale
- Ord
- Method
- IF
Additional Names
- Short Name
- CV2 Ab SerPl Ql IF
- Display Name
- CV2 Ab IF Ql
- Consumer Name Alpha Get Info
- CV2 antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.42
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 12671
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 104992-3 | Paraneoplastic vision loss evaluation panel - Serum |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG14239-4 | CV2 Ab| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | CV2 Anticuerpos: |
| es-MX | Spanish (Mexico) | CV2 Ab: |
| et-EE | Estonian (Estonia) | CV2 antikehad: Synonyms: Järgarvuline Juhuslik Plasma Seerum Seerum või plasma |
| fr-CA | French (Canada) | CV2, Ac: |
| fr-BE | French (Belgium) | CV2 Ac: Synonyms: Anticorps |
| fr-FR | French (France) | CV2 anticorps: |
| it-IT | Italian (Italy) | CV2 Ab: Synonyms: anticorpo Immunofluorescenza (IF) Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | CV2 As: Synonyms: antistof; |
| pt-BR | Portuguese (Brazil) | CV2 Ac: |
| ru-RU | Russian (Russian Federation) | CV2 Ат: Synonyms: Антитело Иммунофлюоресценция (ИФ) Плазма Порядковый Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | CV2 Ab: Synonyms: Ak İmmünflorerans Mevcut |
| zh-CN | Chinese (China) | CV2 抗体: Synonyms: Ab; |
104993-1 Paraneoplastic vision loss [Interpretation] in Specimen Narrative
Fully-Specified Name
- Component
- Paraneoplastic vision loss
- Property
- Imp
- Time
- Pt
- System
- XXX
- Scale
- Nar
- Method
Additional Names
- Short Name
- Paran vis loss Spec-Imp
- Display Name
- Paraneoplastic vision loss Nar (Specimen) [Interp]
- Consumer Name Alpha Get Info
- Interpretation of Paraneoplastic vision loss test result, Specimen
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.78
- Last Updated
- Version 2.78
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 104992-3 | Paraneoplastic vision loss evaluation panel - Serum |