106743-8
Bacillus anthracis lethal factor Ab [Presence] in Serum by Immunoassay
Active
Term Description
This term represents the assay which detects antibodies against the lethal factor component of the anthrax toxin produced by Bacillus anthracis. This assay is crucial for understanding immune responses to anthrax exposure, aiding in diagnosis of anthrax infection, and evaluating vaccine efficacy. It can be performed on serum and venous whole blood samples (using dipotassium EDTA, sodium citrate, or sodium heparin as anticoagulants) from individuals with signs and symptoms consistent with inhalation anthrax and a likelihood of exposure. PMID: 30776143
Part Description
LP444041-0 Bacillus anthracis lethal factor
Bacillus anthracis lethal factor is one of the three components of the anthrax toxin produced by the bacterium Bacillus anthracis, which causes anthrax. This protein acts as a zinc-dependent metalloprotease that, when combined with protective antigen (PA) and entering host cells, disrupts cellular signaling by inactivating mitogen-activated protein kinases (MAPKs), leading to cell death, particularly in immune cells like macrophages, and contributing to the overall pathogenic effects of anthrax infection.
Source: LOINC
Fully-Specified Name
- Component
- Bacillus anthracis lethal factor Ab
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- IA
Additional Names
- Long Common Name
- Bacillus anthracis lethal factor Ab [Presence] in Serum by Immunoassay
- Short Name
- B. anthracis LF Ab Ser Ql IA
- Display Name
- Bacillus anthracis lethal factor Ab IA Ql (S)
- Consumer Name Alpha Get Info
- Bacillus anthracis lethal factor antibody, Blood
Example Answer List: LL6976-6
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.79
- Last Updated
- Version 2.79 (ADD)
- Order vs. Observation
- Observation
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG41626-9 | Bacillus anthracis |
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