113882-5

Cannabinoids [Presence] in Saliva (oral fluid) by Mass Spectrometry

Active

Part Descriptions

LP16058-7 Cannabinoids
The group of drugs called cannabinoids includes both the cannabinoid chemicals found in the cannabis plant as well as synthetic and pharmaceutical cannabinoids. The cannabinoids in cannabis include tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN). THC is responsible for the psychoactive effects of cannabis and binds to the CB1 and CB2 cannabinoid receptors. CBD does not have psychoactive effects but rather has a variety of therapeutic properties including anticonvulsant, analgesic, anti-anxiety, and antiemetic. The THC to CBD ratio determines the physiologic effects of the drug. A high THC/CBD ratio results in euphoric and anxiolytic effects, while a low THC/CBD ratio results in sedative effects. Both natural and synthetic cannabinoid compounds are used for therapeutic purposes. Synthetic cannabinoids, like THC, act on the CB1 and CB2 receptors. Adverse reactions, including psychosis, confusion, agitation, tachycardia, myocardial infarction, seizures, and fatal overdoses, are more common with synthetic cannabinoids compared to cannabis. PMID: 30275754 Source: Regenstrief LOINC

LP7565-7 Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. PMID: 17268583 Source: Regenstrief LOINC

LP262420-5 Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual. PMID: 17268583 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Cannabinoids:PrThr:Pt:Saliva:Ord:Mass Spec
Long Common Name: Cannabinoids [Presence] in Saliva (oral fluid) by Mass Spectrometry
Short Name: Cannabinoids Sal Ql Mass Spec
Display Name: Cannabinoids Mass Spec Ql (Sal)
Consumer Name Alpha Get Info: Cannabinoids, Saliva

Part Model Get Info

Component
Cannabinoids
LP16058-7
- Analyte
  Cannabinoids
  LP16058-7
  - Component Numerator
    Cannabinoids
    LP16058-7
    - Component Numerator Core
      Cannabinoids
      LP16058-7
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Saliva
LP7565-7
- System Core
  Saliva
  LP7565-7
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Mass Spec
LP451714-2

Example Answer List: LL744-4

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
Detected			LA11882-0
Not detected			LA11883-8

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.83
Last Updated: Version 2.83 (ADD)
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG52737-0	Cannabinoids\|PrThr\|Pt\|Saliva

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=113882-5

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.