114149-8

clonazePAM [Mass/volume] in Saliva (oral fluid) by Mass Spectrometry

Active

Part Descriptions

LP16086-8 clonazePAM
Clonazepam is a powerful benzodiazepine that was originally prescribed to treat seizure disorders but has increasingly been used to treat mood disorders including panic disorder and depression. Clonazepam has been used to accelerate the response of selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine and sertraline and for treatment-resistant and prolonged depression. Extended use of clonazepam with SSRIs helps prevent the recurrence of depression. Clonazepam more effectively treats unipolar than bipolar depression. Its mode of action is believed to be associated with the gamma-aminobutyric acid (GABA) system. PMID: 19330803 Source: Regenstrief LOINC

LP7565-7 Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. PMID: 17268583 Source: Regenstrief LOINC

LP262420-5 Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual. PMID: 17268583 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: clonazePAM:MCnc:Pt:Saliva:Qn:Mass Spec
Long Common Name: clonazePAM [Mass/volume] in Saliva (oral fluid) by Mass Spectrometry
Short Name: clonazePAM Sal Mass Spec-mCnc
Display Name: clonazePAM Mass Spec (Sal) [Mass/Vol]
Consumer Name Alpha Get Info: clonazePAM, Saliva

Part Model Get Info

Component
clonazePAM
LP16086-8
- Analyte
  clonazePAM
  LP16086-8
  - Component Numerator
    clonazePAM
    LP16086-8
    - Component Numerator Core
      clonazePAM
      LP16086-8
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Saliva
LP7565-7
- System Core
  Saliva
  LP7565-7
- Super System
  NULL
Scale
Qn
LP7753-9
Method
Mass Spec
LP451714-2

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.83
Last Updated: Version 2.83 (ADD)
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG53047-3	clonazePAM\|MCnc\|Pt\|Saliva

Example Units

Unit	Source
ng/mL	Example UCUM Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=114149-8

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.