114373-4
PHENobarbital [Presence] in Saliva (oral fluid)
Active
Part Descriptions
LP14729-5 PHENobarbital
Phenobarbital is an antiepileptic drug first introduced for clinical use in 1912. It is still used to treat most seizures except for absence seizure types. The CYP2C19 enzyme metabolizes phenobarbital to p-hydroxyphenobarbital which is then excreted as glucuronide. Phenobarbital induces secretion of liver enzymes which can impact the efficacy of drugs administered at the same time. The most common side effect of phenobarbital in adults with blood levels greater than 40 mg/L is sedation. Phenobarbital is an active metabolite of primidone and so must also be monitored in patients on primidone.(Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, Seventh Edition; Carl A. Burtis; David E. Bruns)
Source: Regenstrief LOINC
LP7565-7 Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. PMID: 17268583
Source: Regenstrief LOINC
LP262420-5 Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual. PMID: 17268583
Source: Regenstrief LOINC
LOINC Names Get Info
- Fully-Specified Name
- PHENobarbital:
PrThr: Pt: Saliva: Ord: - Long Common Name
- PHENobarbital [Presence] in Saliva (oral fluid)
- Short Name
- Phenobarb Sal Ql
- Display Name
- PHENobarbital Ql (Sal)
- Consumer Name Alpha Get Info
- PHENobarbital, Saliva
Part Model Get Info
Example Answer List: LL744-4
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Detected | LA11882-0 | ||
| Not detected | LA11883-8 |
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.83
- Last Updated
- Version 2.83 (ADD)
- Order vs. Observation
- Both
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG52882-4 | PHENobarbital| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Φαινοβαρβιτάλη: Synonyms: DRUG/TOX Ord PrThr Pt Σίελος Φαινοβαρβιτάλη |
| es-ES | Spanish (Spain) | Fenobarbital: |
| et-EE | Estonian (Estonia) | Fenobarbitaal: Synonyms: Järgarvuline Juhuslik Sülg |
| fr-BE | French (Belgium) | Phénobarbital: |
| fr-CA | French (Canada) | Phénobarbital: |
| fr-FR | French (France) | Phénobarbital: |
| it-IT | Italian (Italy) | Fenobarbital: Synonyms: Livelli farmacologici e tossicologia Presenza o Soglia Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | fenobarbital: |
| ru-RU | Russian (Russian Federation) | Фенобарбитал: Synonyms: Порядковый Точка во времени; |
| tr-TR | Turkish (Turkey) | Fenobarbital: Synonyms: Mevcut |
| zh-CN | Chinese (China) | 苯巴比妥: Synonyms: C12H12N2O3; |
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LOINC Copyright
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