Log In

Part Descriptions

LP173437-7   O-nortramadol
O-desmethyltramadol (M1) is an active metabolite of tramadol which is a narcotic analgesic used to treat severe pain. [PubChem: Tramadol] Tramadol and M1 work synergistically to relieve pain. M1 activates the opioid receptor responsible for the analgesic effect of tramadol. The parent drug prevents reuptake of norepinephrine and serotonin which inhibits pain signal transmission in the spinal cord. M1 metabolism is highly dependent upon CYP2D6 which influences the efficacy of pain relief experienced by the patient. The predominant adverse side effects associated with tramadol use include nausea, vomiting, sweating, itching, constipation, headache and central nervous system stimulation.(http://boris.unibe.ch/69119/1/01213011-201407000-00007.pdf) Source: Regenstrief LOINC

LP7565-7   Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. PMID: 17268583 Source: Regenstrief LOINC

LP262420-5   Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual. PMID: 17268583 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
O-Nortramadol:MCnc:Pt:Saliva:Qn:Mass Spec
Long Common Name
O-nortramadol [Mass/volume] in Saliva (oral fluid) by Mass Spectrometry
Short Name
O-nortramadol Sal Mass Spec-mCnc
Display Name
O-nortramadol Mass Spec (Sal) [Mass/Vol]
Consumer Name Alpha Get Info
O-nortramadol, Saliva

Part Model Get Info

  • Component
    O-nortramadol
    LP173437-7
    • Analyte
      O-nortramadol
      LP173437-7
      • Component Numerator
        O-nortramadol
        LP173437-7
        • Component Numerator Core
          O-nortramadol
          LP173437-7
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    MCnc
    LP6827-2
  • Time
    Pt
    LP6960-1
  • System
    Saliva
    LP7565-7
    • System Core
      Saliva
      LP7565-7
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    Mass Spec
    LP451714-2

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.83
Last Updated
Version 2.83 (ADD)
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG52990-5O-Nortramadol|MCnc|Pt|Saliva

Example Units

UnitSource
ng/mLExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=114444-3