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Part Description

LP262496-5   Escherichia coli enterotoxigenic heat-labile toxin DNA
Enterotoxigenic Escherichia coli (ETEC) produces a heat-labile (LT) and a heat-stable (ST) enterotoxin, both of which cause severe diarrhea in both humans and animals. ST is an extracellular toxin which is comprised of a methanol-soluble (STa) toxin and a methanol-insoluble (STb) toxin. The sta gene encodes the STa toxin and the stb gene encodes the STb toxin. [UniProt: Q70Q79]; [UniProt: Q70Q73] STa combines to its enterocyte receptor, guanylate cyclase, which causes intestinal secretion and diarrhea. PMID: 8528070 The STb enterocyte receptor is the protein sulfatide. After STb binds to sulfatide, it is engulfed by the enterocyte. It then activates the pertussis toxin-sensitive G protein which opens the ligand-gated calcium ion channel, allowing an influx of calcium ions. A subsequent secretion of chloride ions, stimulation of arachidonic acid release, and production of prostaglandin E2 and 5-dyroxytryptamine leads to an efflux of water, bicarbonate ions, sodium ions, and chloride ions into the intestinal space, all of which leads to watery diarrhea. PMID: 23716609 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Escherichia coli enterotoxigenic heat-labile toxin DNA:PrThr:Pt:{Specimen}:Ord:{Molgen}
Long Common Name
Escherichia coli enterotoxigenic heat-labile toxin DNA [Presence] in Specimen by Molgen
Short Name
ETEC heat-lab tox DNA Spec Ql
Display Name
E. coli enterotoxigenic heat-labile toxin DNA Molgen Ql (Specimen)
Consumer Name Alpha Get Info
Escherichia coli enterotoxigenic heat-labile toxin, Specimen

Part Model Get Info

  • Component
    Escherichia coli enterotoxigenic heat-labile toxin DNA
    LP262496-5
    • Analyte
      Escherichia coli enterotoxigenic heat-labile toxin DNA
      LP262496-5
      • Component Numerator
        Escherichia coli enterotoxigenic heat-labile toxin DNA
        LP262496-5
        • Component Numerator Core
          Escherichia coli enterotoxigenic heat-labile toxin
          LP262497-3
        • Component Numerator Core Suffix
          DNA
          LP32416-7
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    {Specimen}
    LP451871-0
  • Scale
    Ord
    LP7751-3
  • Method
    {Molgen}
    LP452305-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.83
Last Updated
Version 2.83 (ADD)
Order vs. Observation
Both

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=115097-8