1353-2
Yt sup(b) Ag [Presence] on Red Blood Cells
Active
Part Description
LP15250-1 Y little t super little b
The two antigens of the Yt system, Yt^a and Yt^b, are both expressed at birth, however in a slightly lower expression level than seen on adult cells. They were shown to be resistant to trypsin treatment, but sensitive to other protein cleaving enzymes. Antibodies to these antigens were implicated in cases of delayed transfusion reactions but were not reported to have caused hemolytic disease of the newborn. No examples of Yt(a-b-) individuals have been found despite numerous studies. From population studies, Yt^b appeared to be lacking, or of very low incidence, from Orientals, Amer-Indians and southern Africans; Yta was found lacking in approximately one per thousand individuals of European origin.
This system remained unexciting until it was found that both of these antigens were weak or absent from paroxysmal nocturnal hemoglobinuria (PNH) III red blood cells. With a rush of activity in the early 1990's, it was found that the Yt blood group system antigens represented amino acid substitutions on the GPI-linked glycoprotein, acetylcholinesterase (AchE). This protein probably exists as a dimer (pair) in the red cell membrane. Yta and Ytb are equated to substitutions of a hisitidine and asparagine, respectively, at amino acid position 322 on the GPI-linked glycoprotein. AChE has been assigned a chromosome location at 7q22.
Source: Serum, Cells and Rare Fluid Exchange, Yt^a
Fully-Specified Name
- Component
- Y little t super little b Ag
- Property
- PrThr
- Time
- Pt
- System
- RBC
- Scale
- Ord
- Method
Additional Names
- Short Name
- Yt sup(b) Ag RBC Ql
- Display Name
- Yt sup(b) Ag Ql (RBC)
- Consumer Name Alpha Get Info
- Yt sup(b) antigen, Red blood cells
Basic Attributes
- Class
- BLDBK
- Type
- Laboratory
- First Released
- Version 1.0
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 93914-0 | Blood group antigens panel - Red Blood Cells |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-AR | Spanish (Argentina) | [antígeno] Y Y [minúscula] T [superíndice] [minúscula] B [Ag]: |
| es-ES | Spanish (Spain) | Ytb Antígeno: |
| es-MX | Spanish (Mexico) | Y sub t super sub b Ag: |
| et-EE | Estonian (Estonia) | Yt^b antigeen: Synonyms: Erütrotsüüdid Järgarvuline Juhuslik |
| fr-CA | French (Canada) | Y petit t exposant petit b, Ag: |
| fr-FR | French (France) | YT2 (Ytb) antigène: |
| fr-BE | French (Belgium) | Y petit t exposant petit b Ag: Synonyms: Antigène |
| it-IT | Italian (Italy) | Y t minuscola apice b, Ag: Synonyms: Banca del sangue Globuli rossi Presenza o Soglia Punto nel tempo (episodio) Yt^b |
| ko-KR | Korean (Korea, Republic Of) | Yt^b 항원: |
| nl-NL | Dutch (Netherlands) | Y kleine t super kleine b Ag: Synonyms: antigeen rode bloedcellen |
| pt-BR | Portuguese (Brazil) | Y t pequeno b pequeno superior Ag: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Y малое t супер малое b Аг: Synonyms: Порядковый Точка во времени; |
| tr-TR | Turkish (Turkey) | Y küçük t süper küçük b Ag: Synonyms: Antijen Mevcut RBC |
| zh-CN | Chinese (China) | Yt^b 抗原: Synonyms: Ag B 型 B 型抗原 RBC; |
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