Version 2.77

Part Descriptions

LP18494-2   Activated protein C resistance
A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC) which increases the risk of a clotting disorder. The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance. Source: National Library of Medicine, MeSH 2006

LP18494-2   Activated protein C resistance
Activated protein C resistance (APC) has emerged as the most frequent abnormality in patients with idiopathic thrombosis. Patients found to be heterozygous for APC resistence have a seven fold increased risk for venous thrombosis as compared to the general popualtion. Homozygous individuals have an eight fold increased risk of thrombosis. Familial studies and counselling should be considered for positive patients. The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance. Often measured as the ratio of the Appt W APC. Source: Regenstrief Institute

Reference Information

Type Source Reference
Mapping Guidance Regenstrief Help This test detects the mutation that causes the activated protein C resistance. Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations

Fully-Specified Name

Component
Activated protein C resistance
Property
PrThr
Time
Pt
System
Bld
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
aPCR Bld Ql NAA+probe
Display Name
Activated protein C resistance NAA+probe Ql (Bld)
Consumer Name Alpha Get Info
Activated Protein C Resistance, Blood

Basic Attributes

Class
COAG
Type
Laboratory
First Released
Version 1.0k
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: APC-Res. (Ger.Z.)
es-AR Spanish (Argentina) resistencia a la proteína C activada:concentración arbitraria:punto en el tiempo:sangre:ordinal:sonda.amplificación.blanco
es-ES Spanish (Spain) Resistencia a la proteína C activada:PrThr:Punto temporal:Sangre:Ord:Sonda con amplificación dirigida
es-MX Spanish (Mexico) Resistencia a la proteína C activada:Presencia o umbral:Punto temporal:Sangre:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-CA French (Canada) Résistance à la protéine C activée:Présence-Seuil:Temps ponctuel:Sang:Ordinal:Sonde avec amplification de la cible
fr-FR French (France) Protéine C activée résistance:Présence/Seuil:Ponctuel:Sang:Qualitatif:PCR amplification de cible
fr-BE French (Belgium) Résistance à la protéine C activée:PrThr:Temps ponctuel:Sang:Ordinal:Sonde avec amplification de la cible
Synonyms: RPCa
it-IT Italian (Italy) Proteina C attivata, resistenza:PrThr:Pt:Sangue:Ord:Sonda.amp.tar
Synonyms: Presenza o Soglia Punto nel tempo (episodio) Resistenza alla proteina C attivata Sangue Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Studio di coagulazione
ko-KR Korean (Korea, Republic Of) 활성 C 단백 내성:임의농도:검사시점:전혈:순위척도:DNA 탐색자.증폭.표적
nl-NL Dutch (Netherlands) geactiveerd proteïne C-resistentie:aanwezigheid:moment:bloed:ordinaal:probe-detectie
Synonyms: coagulatiemethode probe.amp.tar
pt-BR Portuguese (Brazil) Resistência a Proteína C ativada:ACnc:Pt:SgTotal:Ord:Sonda com limite de detecção da amplificação de alvo
Synonyms: ; Prot C; PC; Autoprothrombin II-a; PR; aPCR; APCr; APC-R; Arbitrary concentration; Point in time; Random; Blood; WB; Whole blood; Ql; Ordinal; QL; Qualitative; Qual; Screen; PCR; Polymerase chain reaction; Transcription mediated amplification; NASBA; Nucleic acid sequence based analysis; SDA; Strand Displacement Amplification; LAT; Ligation-activated transcription; 3SR SR; 3 Self-Sustaining Sequence Replication; LCR; Ligase chain reaction; QBR; Q-Beta Replicase or probe amplification category method; Probe with target amplification; NAAT; TMA; Amp Prb; Probe with ampification; DNA probe; Amplified; Resistanc; Resist; Resistent; Resistant; APC; COAGULATION
ru-RU Russian (Russian Federation) Активированный протеин С резистентность:PrThr:ТчкВрм:Кр:Пор:Проба.усил.миш
Synonyms: Белок Белок C ДНК проба;ДНК зонд Кровь Порядковый Проба с мишени усилением Точка во времени;Момент
tr-TR Turkish (Turkey) Aktiflenmiş protein C resistans:MevcEşik:Zmlı:Kan:Srl:Prob.amf.hdf
Synonyms: Mevcut
uk-UA Ukrainian (Ukraine) Резистентність до активованого протеїну С:Наявність або Поріг:МоментЧасу:Кров:Порядково:Зонд-детекція. цільова аміпліфікація НК
Synonyms: 3 Self-Sustaining Sequence Replication; 3SR SR; Activ; Amplif; Amplification; Amplified; APC; APCr; APC-R; Autoprothrombin II-a; Blood; COAGULATION; DNA NUCLEIC ACID PROBE; DNA probe; Hematology; Heme; LAT; LCR; Ligase chain reaction; Ligation-activated transcription; NAA+probe; NAAT; NASBA; Nucleic acid sequence based analysis; Ordinal; PC; PCR; Point in time; Polymerase chain reaction; PR; Probe amp; Probe with ampification; Probe with target amplification; Prot; Prot C; QBR; QL; Qual; Qualitative; Random; Resist; Resistanc; Resistant; Resistent; Screen; SDA; Strand Displacement Amplification; TMA; Transcription mediated amplification; UniversalLabOrders; WB; Whole blood
zh-CN Chinese (China) 活化蛋白 C 抗性:存在情况或阈值:时间点:全血:序数型:探针法.基因扩增.靶向
Synonyms: APC 抗性;APC 抵抗;aPCR;APC-R;活化 C 蛋白抗性;活化蛋白 C 抗性（Activated protein C resistance，APC-R）;活化蛋白 C 抗性是采用 APC 的 aPTT 与不采用 APC 的 aPTT 之比。;活化蛋白 C 抵抗;活化蛋白 C 抵抗性 C 型;丙;丙型 C 蛋白;PC;自体凝血因子 II-a;自体凝血素 II-a;自体凝血酶原 II-a;自体前凝血酶 II-a;自体因子 II-a;自体第二凝血因子-a;自体第二因子-a;自身凝血因子 II-a;自身凝血素 II-a;自身凝血酶原 II-a;自身前凝血酶 II-a;自身因子 II-a;自身第二凝血因子-a;自身第二因子-a;蛋白 C（Protein C，PC）;蛋白质 C PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 扩增型 扩增性 抗力 抗耐性 抵抗力 抵抗性 时刻;随机;随意;瞬间 活化型蛋白C（Activated protein C，APC） 激活型蛋白C 激活型蛋白C（Activated protein C，APC） 电阻 经过扩增的 耐性 脱氧核糖核酸探针 血;血液 阻力

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