Coproporphyrin [Presence] in 24 hour Urine
4 carboxyl groups Source: Regenstrief Institute
Porphyrins build up among patients with hereditary enzyme disorders known as porphyrias. Porphyrias affect the heme biosynthetic pathway and cause increased urine excretion of porphyrinogens, by-products known as porphyrins and porphyrinogen precursors-including delta aminolevulinic acid (ALA) and porphobilinogen (PBG). Coproporphyrin and uroporphyrin excretion in urine is markedly increased during acute attacks of hereditary coproporphyria. Increased uroporphyrinogen, uroporphyrin, and coproporphyrin excretion occurs in porphyria cutanea tarda. Increased coproporphyrin excretion alone lacks specificity and sensitivity for lead testing and is likely to occur secondary to other diseases. Information from LOINC partner 1 and Jacobs and DeMott Laboratory Test Handbook, 5th edition, DS Jacobs, WR DeMott and DK Oxley, 2001. 2007 08 06. Source: Regenstrief Institute
Part of porphyrin fractionation testing useful in diagnosing porphyrin cutanea tarda, hereditary coproporphyria, and variegate porphyria. Such patients typically will present with profound elevations of porphyrin analytes (e.g. > 5-fold) during acute episodes. Moderate elevations (e.g. < 3-fold) are more often due to medications or environmental factors. Source: Regenstrief LOINC
- Short Name
- Copro 24h Ur Ql
- Display Name
- Coproporphyrin Ql (24H U)
- Consumer Name Alpha Get Info
- Coproporphyrin, Urine
Example Answer List: LL360-9Source: Regenstrief Institute
|PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
- First Released
- Version 1.0k
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
Member of these Panels
|LOINC||Long Common Name|
|43116-3||Porphyrin fractions panel - 24 hour Urine|
Member of these Groups Get Info
|LOINC Group||Group Name|
Language Variants Get Info
Synonyms: Järgarvuline Uriin
Synonyms: 24 Ore Chimica Presenza o Soglia
|ko-KR||Korean (Korea, Republic Of)||코프로포르피린:
|ru-RU||Russian (Russian Federation)||Копропорфирин:
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