Version 2.78

Part Descriptions

LP17728-4   Cells.CD3+CD8+
HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively. Source: Regenstrief Help

LP17728-4   Cells.CD3+CD8+
HIV infection decreases the number of CD4 T-cells, also called T4 helper cells, the ratio of CD4 to CD8 T-cells and the number of CD8+ T-cells. These counts are ordered frequently to guide decisions about anti-retroviral therapy. Laboratories usually report both percentage and absolute count. When you map CD4 and CD8 markers, be careful! Since at least 1997, CDC has required the detection of both CD3+ and CD4+ to identify T4 helper cells, because the CD3 marker is needed to identify T-cell . So, any tests that report T4 helper cells are really reporting cells that carry BOTH the CD3+ and the CD4+ markers. The measure name may be CD3+ CD4+ cells, CD4+ marker, T4 cells or even just CD4+ (a misnomer). Exactly analogous rules apply to CD8+. Measures that include only CD4 or only CD8 in their name are really measuring CD3+CD4+ cells or CD3+CD8+ cells, respectively and should be reported with the LOINC code that includes both of those markers. The panel named T cell subsets will usually contain both CD3 + CD4 and CD3 + CD8 counts. These names assume that one has already gated to lymphocytes only. Lymphocytes are identified by CD45 markers. So a CD45+CD3+CD4+ is a more complicated way to name CD3+C4+ cells and in the context of looking for CD4 helper T cells they are the same . The same applies to other flow cytometer measures that are looking only at lymphocytes (B-cells, NK cells, etc). Source: Regenstrief Help

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

Reference Information

Type Source Reference
Mapping Guidance Regenstrief Help CD3 as well as CD4 are required to identify CD4 T-cells (CD4 helper cell). Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations

Fully-Specified Name

Component
Cells.CD3+CD8+
Property
NCnc
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Short Name
CD3+CD8+ Cells # Bld
Display Name
CD3+CD8+ (T8 suppressor) cells (Bld) [#/Vol]
Consumer Name Alpha Get Info
CD3+CD8+ (T8 Suppressor) Cells, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 1.0k
Last Updated
Version 2.73
Change Reason
Changed Order_Obs from 'Observation Only' to 'Both' to fit current order use cases.
Order vs. Observation
Both
Common Test Rank Get Info
699

Member of these Panels

LOINC Long Common Name
95184-8 Cytomegalovirus T-cell immunodeficiency panel - Blood by Flow cytometry (FC)
49120-9 Immunodeficiency follow-up panel - Specimen by Flow cytometry (FC)
80721-4 Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood
65759-3 T-cell subsets CD4 and CD8 panel - Blood

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Zellen.CD3+CD8+:Anzahl pro Volumen:Zeitpunkt:Blut:Quantitativ:
Synonyms: Zytotoxische T-Lymphozyten; T-Zellen
de-AT German (Austria) Synonyms: Zytotox.T-Z.(8+)abs.
es-AR Spanish (Argentina) células.CD3+CD8+:concentración de número:punto en el tiempo:sangre:cuantitativo:
es-MX Spanish (Mexico) Cells.CD3 + CD8 +:Concentración numérica:Punto temporal:Sangre:Cuantitativo:
es-ES Spanish (Spain) Células CD3+CD8+:Concentración de número:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
et-EE Estonian (Estonia) Rakud.CD3+CD8+:NCnc:Pt:B:Qn:
Synonyms: Juhuslik Kvantitatiivne Veri
fr-CA French (Canada) Cellules.CD3+CD8+:Concentration numérique:Temps ponctuel:Sang:Quantitatif:
fr-BE French (Belgium) Cellules.CD3+CD8+:Concentration numérique:Temps ponctuel:Sang:Quantitatif:
fr-FR French (France) CD3+CD8+:Nombre/Volume:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Cellule.CD3+CD8+:NCnc:Pt:Sangue:Qn:
Synonyms: Cellule CD3 Cellule CD3+CD8+ Concentrazione Numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
ko-KR Korean (Korea, Republic Of) 세포.CD3+CD8+:계수/부피:검사시점:전혈:정량:
nl-NL Dutch (Netherlands) cellen.CD3+CD8+:aantal/volume:moment:bloed:kwantitatief:
pt-BR Portuguese (Brazil) Células.CD3+CD8+:NCnc:Pt:SgTotal:Qn:
Synonyms: ; CD3+CD8+ Cells; CD3 Cells; Cell; Cellularity; Leu-4; Leu4; T3; #; Number concentration; Count/mass; Count; AcS; CT; Acsolute; Acsolutes; Cnt; Point in time; Random; Blood; WB; Whole blood; Quantitative; QNT; Quant; Quan; Leu-2; T-8; Leu2; Suppressor T cells; T8; Tsuppressor; CELL MARKERS
ru-RU Russian (Russian Federation) Клетки.CD3+CD8+:КолОб:ТчкВрм:Кр:Колич:
Synonyms: CD3+CD8+ (T8 клетки-супрессоры) клетки Количественный Количество в объеме Кровь Точка во времени;Момент
tr-TR Turkish (Turkey) Hücreler.CD3+CD8+:SayKons:Zmlı:Kan:Kant:
uk-UA Ukrainian (Ukraine) Клітини.CD3+CD8+:Чисельна Концентрація:МоментЧасу:Кров:Кількісно:
Synonyms: #; ABS; absolute; absolutes; Blood; CD3 Cells; CD3+CD8+ Cells; CD8 T cells; Cell; CELL MARKERS; Cellularity; Cnt; Count; Count/volume; CT; Leu2; Leu-2; Leu4; Leu-4; Number concentration; Number Concentration (count/vol); Point in time; QNT; Quan; Quant; Quantitative; Random; Suppressor T cells; Suppressor/cytotoxic T cells; T3; T8; T-8; T8 suppressor cells; Tsuppressor; WB; Whole blood
zh-CN Chinese (China) 细胞.CD3+CD8+:计数型浓度:时间点:全血:定量型:
Synonyms: CD3+CD8+细胞 CD3细胞 Leu2 Leu-2 Leu4;Leu-4;T3 T8 T-8 Tsuppressor 单位体积内的数量或计数;数量型浓度(单位体积);数量或计数型浓度(计数/体积);数量或计数型浓度(单位体积);计数型浓度(单位体积) 发现于 抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 抑制性 T 细胞 抑制性 T-细胞 时刻;随机;随意;瞬间 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液

Example Units

Unit Source
#/mm3 REGENSTRIEF
/uL Example UCUM Units
10^9/L eCHN

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=14135-8