Version 2.77

Status Information

Status
DEPRECATED
Reason
Duplicate
Map-To Long Common Name Mapping Guidance
4656-5 Interleukin 7 [Units/volume] in Serum or Plasma

Part Descriptions

LP16475-3   Interleukin 7
Interleukin 7 (IL7) is a protein[1] that is encoded by the IL7 gene in humans.

IL-7 a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, neurons and endothelial cells, but is not produced by lymphocytes. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells (as opposed to myeloid progenitor cells where differentiation is stimulated by IL-3). It also stimulates proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells). It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis.

IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.

IL-7 receptor knockout mice exhibit thymic atrophy, arrest of T-cell development at the double positive stage, and severe lymphopenia. Administration of IL-7 to mice results in an increase in thymic migrants, increases in B and T cells, and increased recovery of T cells after cyclophosphamide administration or after bone marrow transplantation.

Il-7 promotes hematological malignacies (acute lymphoblastic leukemia, T cell lymphoma). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP16475-3   Interleukin 7
The Interleukins belong to the family termed cytokines. They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells. Interleukin 7 is a 25,000 molecular weight glycoprotein produced primarily in bone marrow stromal cells. Its primary target cells are B cells. Interleukin 7 supports long term culture of B cells. Interleukin 7 plays an important role in maintenance of a population of pre B lymphocytes although it does not stimulate differention of pre B cells to B cells. Interleukin 7 also activates myeloid cell proliferation and differentiation. Source: Inter Science Institute, Inter Science Institute

Fully-Specified Name

Component
Interleukin 7
Property
ACnc
Time
Pt
System
Ser
Scale
Qn
Method

Additional Names

Short Name
Deprecated Il7 Ser-aCnc
Display Name
Interleukin 7 Qn (S)
Consumer Name Alpha Get Info
Interleukin 7, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0l
Last Updated
Version 2.69

Member of these Groups Get Info

LOINC Group Group Name
LG5070-0 Interleukin 7|ACnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) interleucina 7:concentración arbitraria:punto en el tiempo:suero:cuantitativo:
es-ES Spanish (Spain) Interleuquina 7:Concentración arbitraria:Punto temporal:Suero:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Interleucina 7:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:
fr-CA French (Canada) Interleukine 7:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:
fr-BE French (Belgium) Interleukine 7:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:
Synonyms: Il7
it-IT Italian (Italy) Interleuchina 7:ACnc:Pt:Siero:Qn:
Synonyms: Chimica Concentrazione Arbitraria Punto nel tempo (episodio) Siero
nl-NL Dutch (Netherlands) interleukine 7:eenheid/volume:moment:serum:kwantitatief:
pt-BR Portuguese (Brazil) Interleucina 7:ACnc:Pt:Soro:Qn:
Synonyms: ; Il7; IL-7; Lymphopoietin-1; IL7; Arbitrary concentration; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; IL; Chemistry
ru-RU Russian (Russian Federation) Интерлейкин 7:ПроизвКонц:ТчкВрм:Сыв:Колич:
Synonyms: Количественный Произвольная концентрация Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) İnterlökin 7:SçKons:Zmlı:Ser:Kant:
zh-CN Chinese (China) 白细胞介素 7:任意型浓度:时间点:血清:定量型:
Synonyms: I L7;Il7;IL-7;Lymphopoietin-1;促淋巴细胞生成素-1;白介素 7;白介素-7;白细胞介素-7 IL 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 白介 白介素 白细胞介素（Interleukin，白介素，IL）

Example Units

Unit Source
[arb'U]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=17023-3