LOINC
Version 2.72

20862-9Influenza virus A Ab [Presence] in Serum by Hemagglutination inhibitionActive

Part Descriptions

LP14239-5   Influenza virus A
Influenza viruses, from the family Orthomyxoviridae, are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C are medically relevant to humans. Aquatic birds harboring avian IAV are the likely natural reservoir for all known IAV subtypes and are probably the original source of all human pandemic IAV strains. IAV maintained in wild birds have been associated with stable host switch events to novel hosts, including most often to domestic poultry but also to horses, swine, toothed whales and humans. The influenza virus life cycle begins with the binding of viral HA to host cell receptors. Endocytosis and HA-mediated fusion of the viral and cellular membranes occurs. Viral ribonucleoprotein complexes are released into the cytoplasm, travel to the nucleus, then are replicated and transcribed by the viral polymerase complex. The new viruses are formed and bud when the newly formed ribonucleicprotein complexes and structural proteins reach the plasma membrane. Further research is needed to better understand how IAVs switch hosts and the viral genetic changes that underlie human adaptation. IAV causes respiratory infections in humans ranging from asymptomatic to fatal. Pandemics are attributed to "novel" viruses which possess a viral hemagglutinin (HA) to which humans do not have immunity. [PMID:20542248] [PMID:25812763]
Influenza viruses A and B are single-stranded RNA enveloped viruses belonging to the Orthomyxoviridae family. The symptoms of infection of Influenza A and B include fever, cough, sore throat, rhinorrhea, nasal congestion, headache, myalgia and malaise. Some patients may experience gastrointestinal symptoms including watery diarrhea, vomiting and abdominal pain. The influenza viruses spread rapidly in enclosed spaces with a documented rate of infection of 70% following a common source of exposure. Infection occurs in the respiratory epithelium in both the upper and lower respiratory tract, and the virus can be found in many specimen types, including nasal aspirates, nasal or nasopharyngeal swabs, throat swabs, sputum and tracheal aspirates. When infection rates reach epidemic proportions, hospitalization of children and elderly patients rises as does the mortality rates of elderly patients.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

LP6304-2   HAI
The hemagglutination-inhibition assay (HAI) can be used to identify subtypes of hemagglutinin producing viruses, such as Influenza. HAI can also be used to identify the subtype-specificity of antibodies against the virus. Normally, Influenza's hemagglutinin glycoprotein binds to receptors on the surface of red blood cells, causing them to agglutinate. If antibodies specific to the virus are present in the patient sample, they will bind to the virus, which prevents the virus from binding to the red blood cells and therefore prevents agglutination. To determine which subtype of virus is present, a viral isolate is tested against a series of antibodies with known subtype specificities. Whichever antibody inhibits red cell agglutination identifies the viral subtype. Similarly, antibody specificity is identified by testing the patient sample against known virus subtypes. [PMID:24899416] Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus A Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
HAI

Additional Names

Short Name
FLUAV Ab Ser Ql HAI
Display Name
FLUAV Ab HAI Ql (S)
Consumer Name Alpha
Influenza A (Flu A) antibody, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 1.0m
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups

LG32757-3 Influenza virus

Language Variants Get Info

zh-CNChinese (China)
流感病毒 A 型 抗体:存在情况或阈值:时间点:血清:序数型:红细胞凝集抑制试验法
nl-NLDutch (Netherlands)
Influenzavirus A As:aanwezigheid:moment:serum:ordinaal:hemagglutinatieremming
et-EEEstonian (Estonia)
A-gripi viirus antikehad:PrThr:Pt:S:Ord:HAI
fr-BEFrench (Belgium)
Virus de l'influenza A Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Inhibition de l'hémagglutination
fr-CAFrench (Canada)
Virus de l'influenza A , Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Inhibition de l'hémagglutination
fr-FRFrench (France)
Influenza virus A Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Hémagglutination indirecte
it-ITItalian (Italy)
Influenza A, virus Ab:PrThr:Pt:Siero:Ord:HAI
ko-KRKorean (Korea, Republic of)
A형 인플루엔자 바이러스 항체:임의농도:검사시점:혈청:순위척도:적혈구응집 억제
pt-BRPortuguese (Brazil)
Influenza vírus A Ac:ACnc:Pt:Soro:Ord:Inibição da hemaglutinação
es-ARSpanish (Argentina)
virus Influenza aviario:concentración arbitraria:punto en el tiempo:suero:ordinal:inhibición de la hemoaglutinación
es-MXSpanish (Mexico)
Virus de la influenza A Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Inhibición de la hemaglutinación
es-ESSpanish (Spain)
Virus Influenza A Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inhibición de la Hemaglutinación
tr-TRTurkish (Turkey)
İnfluenza virüsü A Ab:MevcEşik:Zmlı:Ser:Srl:HAI

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