21207-6
CCR5 gene mutations found [Identifier] in Blood by Molecular genetics method Nominal
Active
Part Description
LP19680-5 CCR5 gene
The CCR5 gene (chemokine (C-C motif) receptor 5 (gene/pseudogene)) [HGNC Gene ID:1606] is located on chromosome 3p21.31. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] [NCBI Gene ID:1234]
Source: National Center for Biotechnology Information (NCBI) Gene
Fully-Specified Name
- Component
- CCR5 gene targeted mutation analysis
- Property
- Prid
- Time
- Pt
- System
- Bld
- Scale
- Nom
- Method
- Molgen
Additional Names
- Short Name
- CCR5 gene Mut Anl Bld
- Display Name
- CCR5 gene targeted mutation analysis Molgen Nom (Bld)
- Consumer Name Alpha Get Info
- CCR5 gene targeted mutation analysis, Blood
Basic Attributes
- Class
- MOLPATH.MUT
- Type
- Laboratory
- First Released
- Version 1.0m
- Last Updated
- Version 2.63
- Change Reason
- Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Gen CCR5 Analisis de mutaciones: |
| es-AR | Spanish (Argentina) | análisis de la mutación del gen CCR5: |
| es-MX | Spanish (Mexico) | Análisis de mutaciones dirigidas al gen CCR5: |
| fr-FR | French (France) | CCR5 gène mutation cible trouvée: |
| it-IT | Italian (Italy) | CCR5, gene analisi di mutazione mirata: Synonyms: Gene CCR5 Genetica molecolare Mutazione genica Patologia molecolare Presenza o Identità Punto nel tempo (episodio) Sangue |
| ko-KR | Korean (Korea, Republic Of) | CCR5 유전자 돌연변이 분석: |
| nl-NL | Dutch (Netherlands) | CCR5-gen doelgerichte mutatie-analyse: Synonyms: CCR5 gen molgen targeted |
| pt-BR | Portuguese (Brazil) | CCR5 análise de mutação genética: Synonyms: CKR5; |
| ru-RU | Russian (Russian Federation) | CCR5 ген исследование на мутацию: Synonyms: Кровь Номинальный; |
| tr-TR | Turkish (Turkey) | CCR5 geni Mutasyon analizi: |
| zh-CN | Chinese (China) | CCR5 基因 突变分析: Synonyms: CCCKR5; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=21207-6
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