21551-7

t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript [Presence] in Blood or Tissue by Molecular genetics method

Active

Part Description

LP150268-3 t(15;17)(q24.1;q21.1)(PML,RARA)
The fusion of promyelocytic leukemia (PML, chromosome 15q24.1) and retinoic acid receptor alpha (RARA, chromosome 17q21.1) genes occurs due to a chromosomal translocation. The fused genes can be detected by various molecular techniques, including FISH and real-time quantitative polymerase chain reaction (RT-qPCR). The test is used to diagnose Acute Promyelocytic Leukemia (APL), detect residual or recurrent APL, and to monitor PML-RARA levels in patients with APL. The assay can be done on whole blood (plasma or cell-based) and bone marrow. Long, variant and/or short isoforms of PML-RARA fusion transcripts may be identified. The ratio of PML-RARA fusion transcript to a control gene (e.g. ABL1) may be reported for positive samples. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript:Arb:Pt:Bld/Tiss:Ord:Molgen
Long Common Name: t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript [Presence] in Blood or Tissue by Molecular genetics method
Short Name: t(15;17)(PML,RARA) Bld/T Ql
Display Name: t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript Molgen Ql (Bld/Tiss)
Consumer Name Alpha Get Info: t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript analysis, Blood or tissue specimen

Part Model Get Info

Component
t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript
LP229745-7
- Analyte
  t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript
  LP229745-7
  - Component Numerator
    t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript
    LP229745-7
    - Component Numerator Core
      t(15;17)(q24.1;q21.1)(PML,RARA)
      LP150268-3
    - Component Numerator Core Suffix
      fusion transcript
      LP150217-0
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
Arb
LP6781-1
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld/Tiss
LP7061-7
- System Core
  Bld/Tiss
  LP7061-7
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Molgen
LP6404-0

Basic Attributes

Class: MOLPATH.TRNLOC
Type: Laboratory
First Released: Version 1.0m
Last Updated: Version 2.73 (MIN)
Change Reason: Updated Component part to harmonize with ISCN guidelines and current LOINC nomenclature.; Changed Order_Obs from 'Observation Only' to 'Both' to fit current order use cases.
Order vs. Observation: Both
Common Test Rank Get Info: 6070

Member of these Panels

LOINC	Long Common Name
72103-5	Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Fúzní transkript t(15;17)(q24.1;q21.1)(PML,RARA):Arbitrární:Časový bod:Krev/tkáň:Ordinální:Molekulární genetika
de-AT	German (Austria)	Synonyms: PML-RARa t(15,17)
el-GR	Greek (Greece)	t(15;17)(q24.1;q21.1)(PML,RARA) μεταγραφή συγχώνευσης:Arb:Pt:Αίμα/Ιστός:Ord:Μοριακή γενετική Synonyms: Arb MOLPATH MOLPATH.TRNLOC Ord PML Pt t(15;17)(q24.1;q21.1)(PML,RARA) Αίμα Αίμα/Ιστός Ιστός μεταγραφή συγχώνευσης Μοριακή γενετική
es-AR	Spanish (Argentina)	translocación del gen T(15,17)(PML,RARA):arbitrario:punto en el tiempo:sangre entera/tejido:ordinal:genética molecular
es-ES	Spanish (Spain)	t(15;17)(q24.1;q21.1)(PML,RARA) Tránscritos de fusión:Arbitrario:Punto temporal:Sangre o tejido:Ord:Genética molecular
es-MX	Spanish (Mexico)	t (15; 17) (q24.1; q21.1) (PML, RARA) transcripción de fusión:Arbitrario:Punto temporal:Sangre o tejido:Ordinal:Genética molecular
fr-CA	French (Canada)	t(15;17)(q24.1;q21.1)(PML,RARA) transcrit de fusion:Arbitraire:Temps ponctuel:Sang/Tissu:Ordinal:Molgen
fr-FR	French (France)	t(15;17)(q24.1;q21.1)(PML,RARA) transcript de fusion:Arbitraire:Ponctuel:Sang/Tissu:Qualitatif:Biologie moléculaire
it-IT	Italian (Italy)	t(15,17)(q24.1,q21.1)(PML,RARA), trascritto di fusione:Arb:Pt:Sangue/Tess:Ord:Molgen Synonyms: Arbitrario Genetica molecolare Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci Traslocazione genetica
ko-KR	Korean (Korea, Republic Of)	t(15,17)(PML,RARA) 유전자 전위:임의적분:검사시점:전혈/조직:순위척도:분자유전
nl-NL	Dutch (Netherlands)	t(15;17)(q24.1;q21.1)(PML,RARA) fusietranscript:aanwezigheid:moment:bloed of weefsel:ordinaal:moleculair genetisch onderzoek Synonyms: molgen
pt-BR	Portuguese (Brazil)	t(15,17)(PML,RARA) translocação do gene:Arb:Pt:Sg/Tecido:Ord:Genética molecular Synonyms: Arbitrary; Point in time; Random; Bld/T; Tissue; Bld/T; Blood; WB; Whole blood; Ql; Ordinal; QL; Qualitative; Qual; Screen; PCR; Molecular genetics; Myelogenous; Acute promyelocytic leukemia; APL; t(15,17)(q22,q11.2-q12); T prime; Retinoic acid receptor alpha; RAR alpha form; NR1B1; RARalpha; Promyelocytic leukemia; MYL; PML-1; PML-2; PML-3; PML-3B; PML-X; MOLPATH.TRANSLOCATION; MOLPATH.TRANSLOCATION; Molecular pathology
ru-RU	Russian (Russian Federation)	t(15;17)(q24.1;q21.1)(PML,RARA) слияния транскрипт:Произв:ТчкВрм:Кр/Тк:Пор:МолГен Synonyms: Кровь Кровь или Ткань Порядковый Произвольный Промиелоцитарный лейкоз Ткань и мазки Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TR	Turkish (Turkey)	t(15;17)(q24.1;q21.1)(PML,RARA) füzyon transkript:Sç:Zmlı:Kan/Dk:Srl:Molgen
zh-CN	Chinese (China)	t(15;17)(q24.1;q21.1)(PML,RARA) 融合转录物:任意型:时间点:全血/组织:序数型:分子遗传学类实验室方法 Synonyms: MYL NR1B1 PML-1 PML-2 PML-3 PML-3B PML-X RAR alpha 型 RAR α型 RARalpha RARα 任意;任意的;人工型依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型全血或组织;血液/组织;血液或组织分子病理学.基因易位;分子病理学.易位;分子病理学试验.基因易位;分子病理学试验.易位;分子病理学试验类.易位;基因易位分子病理学;分子病理学试验分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应前髓细胞白血病早幼粒细胞性白血病早幼粒细胞白血病早幼粒细胞白血病（Promyelocytic leukemia，PML）时刻;随机;随意;瞬间易位(15;17)(q24.1;q21.1)(PML,RARA) 未作说明的组织;组织;组织 & 涂片融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录血;血液视黄酸受体 alpha 视黄酸受体 alpha（Retinoic acid receptor alpha，RARA，RARalpha，RAR alpha）视黄酸受体 α

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.