Version 2.78

Part Description

LP19492-5   Thiopurine methyltransferase
Thiopurine methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs including 6-mercatptopurine, thioguanine, and azathioprine (AZA). These drugs are used to treat acute lymphoblastic leukemia, inflammatory bowel disease, rheumatoid arthritis, and organ transplant rejection. Patients with low or absent TPMT activity are at increased risk for toxicity due to increased accumulation of unmetabolised drug. Information from Current Clinical Pharmacology. 2006;1:119-128. Source: Regenstrief Institute

Fully-Specified Name

Component
Thiopurine methyltransferase
Property
CCnc
Time
Pt
System
RBC
Scale
Qn
Method

Additional Names

Short Name
TPMT RBC-cCnc
Display Name
Thiopurine methyltransferase (RBC) [Catalytic activity/Vol]
Consumer Name Alpha Get Info
Thiopurine methyltransferase, Red blood cells

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0m
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
3408

Member of these Groups Get Info

LOINC Group Group Name
LG50142-5 Thiopurine methyltransferase|CCnc|Pt|RBC

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) tiopurina metiltransferasa:concentración catalítica:punto en el tiempo:eritrocitos:cuantitativo:
es-ES Spanish (Spain) Tiopurina metiltransferasa:Concentración Catalítica:Punto temporal:Glóbulos rojos:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Tiopurina metiltransferasa:Concentración catalítica:Punto temporal:Eritrocitos:Cuantitativo:
et-EE Estonian (Estonia) Tiopuriini metüültransferaas:CCnc:Pt:RBC:Qn:
Synonyms: Erütrotsüüdid Juhuslik Kvantitatiivne
fr-CA French (Canada) Thiopurine méthyltransférase:Concentration catalytique:Temps ponctuel:GR:Quantitatif:
fr-FR French (France) Thiopurine méthyltransférase:Catalytique/Volume:Ponctuel:Érythrocytes:Numérique:
fr-BE French (Belgium) Thiopurine méthyltransférase:Concentration catalytique:Temps ponctuel:GR:Quantitatif:
it-IT Italian (Italy) Tiopurina metiltransferasi:CCnC:Pt:RBC:Qn:
Synonyms: Chimica Concentrazione Catalitica Globuli rossi Punto nel tempo (episodio)
ko-KR Korean (Korea, Republic Of) Thiopurine methyltransferase:촉매농도:검사시점:적혈구:정량:
nl-NL Dutch (Netherlands) thiopurinemethyltransferase:enzymatische activiteit/volume:moment:erytrocyten:kwantitatief:
Synonyms: rode bloedcellen
pt-BR Portuguese (Brazil) Tiopurina metiltransferase:CCnc:Pt:Eritroc:Qn:
Synonyms: ; TPMT; Catalytic Concentration; Point in time; Random; Erythrocytes; Red blood corpusles; Red blood cells; Quantitative; QNT; Quant; Quan; Methyl transferase; Chemistry
ru-RU Russian (Russian Federation) Тиопурин метилтрансфераза:КаталКонц:ТчкВрм:Эритроциты:Колич:
Synonyms: Каталитическая концентрация Количественный Тиопурин-S-метилтрансфераза Точка во времени;Момент
tr-TR Turkish (Turkey) Tiyopürin metiltransferaz:KtlKons:Zmlı:Eritrosit:Kant:
Synonyms: RBC
zh-CN Chinese (China) 硫嘌呤甲基转移酶:催化浓度:时间点:红细胞:定量型:
Synonyms: RBC;RBCS;红血球;红血细胞;赤血球 TPMT;巯嘌呤甲基转移酶 催化浓度(单位体积);单位体积内酶的单位数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 转甲基酶

Example Units

Unit Source
U/ML RBC REGENSTRIEF
U/mL{RBCs} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=21563-2