23381-7

Abnormal Prion Protein [Presence] in Brain by Electron microscopy

Active

Term Description

Characteristic fibrils identified.

Part Description

LP35078-2 Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Transmissible spongiform encephalopathy

LOINC Names Get Info

Fully-Specified Name: Prion protein.abnormal:PrThr:Pt:Brain:Ord:Microscopy.electron
Long Common Name: Abnormal Prion Protein [Presence] in Brain by Electron microscopy
Short Name: Abn Prion Prot Brain Ql EM
Display Name: Abnormal Prion Protein EM Ql (Brain)
Consumer Name Alpha Get Info: Abnormal prion protein, Brain

Part Model Get Info

Component
Prion protein.abnormal
LP35078-2
- Analyte
  Prion protein.abnormal
  LP35078-2
  - Component Numerator
    Prion protein.abnormal
    LP35078-2
    - Component Numerator Core
      Prion protein.abnormal
      LP35078-2
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Brain
LP7084-9
- System Core
  Brain
  LP7084-9
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Microscopy.electron
LP6395-0

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 1.0n
Last Updated: Version 2.56 (MAJ)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Prionový protein abnormální:Přítomnost nebo práh:Časový bod:Mozek:Ordinální:Mikroskopie elektronová
de-DE	German (Germany)	Prionenprotein.abnorm:Nachweis oder Schwellenwert:Zeitpunkt:Gehirn:Ordinal:Mikroskopie.Elektronen
el-GR	Greek (Greece)	Πρωτεΐνη πριόν.μη φυσιολογική:PrThr:Pt:Εγκέφαλος:Ord:Μικρoσκόπηση.ηλεκτρονική Synonyms: MICRO Ord PrThr Pt Εγκέφαλος Μικρoσκόπηση.ηλεκτρονική Μικρoσκόπιση Πρωτεΐνη Πρωτεΐνη πριόν.μη φυσιολογική
es-AR	Spanish (Argentina)	proteína de prion:concentración arbitraria:punto en el tiempo:cerebro:ordinal:microscopia.electrónica
es-ES	Spanish (Spain)	Proteína priónica anormal:PrThr:Punto temporal:Cerebro:Ord:Microscopía electrónica
es-MX	Spanish (Mexico)	Proteína priónica anormal:Presencia o umbral:Punto temporal:Cerebro:Ordinal:Microscopio de electrones
fr-CA	French (Canada)	Protéines prion.anormales:Présence-Seuil:Temps ponctuel:Cerveau:Ordinal:Microscopie.électronique
fr-FR	French (France)	Protéine prion anormale:Présence/Seuil:Ponctuel:Cerveau:Qualitatif:Microscopie électronique
fr-BE	French (Belgium)	Protéines prion.anormales:PrThr:Temps ponctuel:Cerveau:Ordinal:Microscopie.électronique
it-IT	Italian (Italy)	Proteina prionica.anormale:PrThr:Pt:Cervello:Ord:Microscopia.elettronica Synonyms: Microbiologia Microscopia elettronica Presenza o Soglia Proteina Prionica Anormale Punto nel tempo (episodio)
ko-KR	Korean (Korea, Republic Of)	프리온 단백.이상:임의농도:검사시점:뇌:순위척도:전자현미경
nl-NL	Dutch (Netherlands)	prioneiwit.abnormaal:aanwezigheid:moment:hersenen:ordinaal:microscopie.electronen Synonyms: electronenmicroscopie
pl-PL	Polish (Poland)	Białko prionowe.nieprawidłowe:granica wykrywalności:punkt w czasie:mózg:uporządkowany:mikroskopia elektronowa Synonyms: Nieprawidłowe białko prionowe
pt-BR	Portuguese (Brazil)	Proteína prion.anormal:ACnc:Pt:Cérebro:Ord:Microscopia eletrônica Synonyms: ; Prot; PR; Acn Prion Prot; Scrapie; Bovine spongiform encephalopathy; BSE; Arbitrary concentration; Point in time; Random; Cerebrum; Head; Cerebral; Intracranial; Ql; Ordinal; QL; Qualitative; Qual; Screen; EM; Micros; Microscopic; Acn; Acnorm; Microbiology
tr-TR	Turkish (Turkey)	Prion protein.anormal:MevcEşik:Zmlı:Beyin:Srl:Mikroskopi.elektron Synonyms: Mevcut
zh-CN	Chinese (China)	朊病毒蛋白.异常:存在情况或阈值:时间点:脑部:序数型:显微镜检查.电子 Synonyms: BSE;Scrapie;亲染子蛋白.异常;异常亲染子蛋白;异常感染性蛋白质;异常朊病毒蛋白;异常蛋白感染素;感染性蛋白质.异常;牛海绵状脑病;牛海绵状脑病（Bovine spongiform encephalopathy，BSE）;疯牛病;羊痒病;羊瘙痒病;羊瘙痒病（Scrapie）;蛋白感染素.异常 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质不平常的不正常的亲染子蛋白依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型反常的大脑;大脑的;头;头部;头颅内;头颅内的;脑的;脑;颅内;颅内的;颅骨内;颅骨内的存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）异常的微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）感染性蛋白质时刻;随机;随意;瞬间显微学;显微术;显微镜学;显微镜检术;显微镜检查;显微镜检查方法;显微镜检查法;显微镜检查类方法;显微镜检查类检验方法;显微镜法;镜检;镜检术;镜检法显微镜方法.电子;显微镜检.电子;电子显微镜方法;电子显微镜检;电子显微镜检查;电镜检查;电镜法;镜查.电子蛋白感染素非一般的非惯例的

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.