23585-3
Western equine encephalitis virus neutralizing antibody [Presence] in Serum by Neutralization test
Active
Part Descriptions
LP14237-9 Western equine encephalitis virus
Western equine encephalitis (WEE) is a relatively uncommon viral infection caused by the WEE virus, an Alphavirus of the family Togaviridae. WEE virus is an [arbovirus] (arthropod-borne virus) transmitted by mosquitoes of the genera Culex and Culiseta. There have been under 700 confirmed cases in the U.S. since 1964. In the U.S. WEE is seen mainly in states west of the Mississippi River. The disease is also seen in countries of South America. WEE is commonly a subclinical infection; symptomatic infections are uncommon. However, the disease can cause serious sequellae in infants and children. Unlike Eastern equine encephalitis, the overall mortality of WEE is low (approximately 4%) and is associated mostly with infection in the elderly. There is no vaccine for WEE and there are no licensed therapeutic drugs in the U.S. for this infection.
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Source: Wikipedia, Western equine encephalitis virus (Wikipedia)
LP207365-0 Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method.
Source: Regenstrief LOINC
LP6416-4 Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Western equine encephalitis virus Ab.Neut
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- Neut
Additional Names
- Short Name
- WEEV NAb Ser Ql Nt
- Display Name
- WEEV neut ab Neut test Ql (S)
- Consumer Name Alpha Get Info
- WEEV neutralizing antibody, Blood
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 1.0n
- Last Updated
- Version 2.72
- Change Reason
- Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG32759-9 | Western equine encephalitis virus |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-AR | Spanish (Argentina) | [anticuerpo anti - ] virus de la encefalitis equina del oeste [Ac]: |
| es-ES | Spanish (Spain) | Virus encefalitis equina del oeste Anticuerpos antineutrófilos: |
| es-MX | Spanish (Mexico) | Virus de la encefalitis equina occidental Ab: |
| fr-CA | French (Canada) | Virus de l'encéphalite équine de l'Ouest Ac.neut: |
| it-IT | Italian (Italy) | Encefalite equina occidentale, virus Ab.Neut: Synonyms: anticorpo Microbiologia Presenza o Soglia Punto nel tempo (episodio) Siero Test di neutralizzazione Virus dell''encefalite equina occidentale |
| ko-KR | Korean (Korea, Republic Of) | 서부마 뇌염 바이러스 항체: |
| nl-NL | Dutch (Netherlands) | Westers equien encefalitisvirus As.neutraliserend: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Wirus zachodniego zapalenia mózgu koni Ab.Neutralizujące: Synonyms: Przeciwciała do wirusa zachodniego zapalenia mózgu koni Przeciwciała neutralizujące do wirusa zachodniego zapalenia mózgu koni Wirus zachodniego zapalenia mózgu koni |
| pt-BR | Portuguese (Brazil) | Encefalite equina ocidental vírus Ac: Synonyms: ; |
| zh-CN | Chinese (China) | 西方马脑炎病毒 抗体.中和: Synonyms: Ab; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright