24467-3

CD3+CD4+ (T4 helper) cells [#/volume] in Blood

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Part Descriptions

LP14441-7 Cells.CD3+CD4+
HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively. Source: Regenstrief Help

LP14441-7 Cells.CD3+CD4+
HIV infection decreases the number of CD4 T-cells, also called T4 helper cells, the ratio of CD4 to CD8 T-cells and the number of CD8+ T-cells. These counts are ordered frequently to guide decisions about anti-retroviral therapy. Laboratories usually report both percentage and absolute count. When you map CD4 and CD8 markers, be careful! Since at least 1997, CDC has required the detection of both CD3+ and CD4+ to identify T4 helper cells, because the CD3 marker is needed to identify T-cell . So, any tests that report T4 helper cells are really reporting cells that carry BOTH the CD3+ and the CD4+ markers. The measure name may be CD3+ CD4+ cells, CD4+ marker, T4 cells or even just CD4+ (a misnomer). Exactly analogous rules apply to CD8+. Measures that include only CD4 or only CD8 in their name are really measuring CD3+CD4+ cells or CD3+CD8+ cells, respectively and should be reported with the LOINC code that includes both of those markers. The panel named T cell subsets will usually contain both CD3 + CD4 and CD3 + CD8 counts. These names assume that one has already gated to lymphocytes only. Lymphocytes are identified by CD45 markers. So a CD45+CD3+CD4+ is a more complicated way to name CD3+C4+ cells and in the context of looking for CD4 helper T cells they are the same . The same applies to other flow cytometer measures that are looking only at lymphocytes (B-cells, NK cells, etc). Source: Regenstrief Help

LP14443-3 CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

Reference Information

Type	Source	Reference
Mapping Guidance	Regenstrief Help	CD3 as well as CD4 are required to identify CD4 T-cells (CD4 helper cell). Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations

Fully-Specified Name

Component: Cells.CD3+CD4+
Property: NCnc
Time: Pt
System: Bld
Scale: Qn
Method

Additional Names

Short Name: CD3+CD4+ Cells # Bld
Display Name: CD3+CD4+ (T4 helper) cells (Bld) [#/Vol]
Consumer Name Alpha Get Info: CD3+CD4+ (T4 Helper) Cells, Blood

Basic Attributes

Class: CELLMARK
Type: Laboratory
First Released: Version 1.0o
Last Updated: Version 2.73
Order vs. Observation: Both
Common Test Rank Get Info: 621

Member of these Panels

LOINC	Long Common Name
80721-4	Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood
65758-5	T-cell helper (CD4) subset panel - Blood
65759-3	T-cell subsets CD4 and CD8 panel - Blood

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	Zellen.CD3+CD4+:Anzahl pro Volumen:Zeitpunkt:Blut:Quantitativ:
de-AT	German (Austria)	Synonyms: Helfer-T-Z.(4+) abs.
es-AR	Spanish (Argentina)	células.CD3+CD4+:concentración de número:punto en el tiempo:sangre:cuantitativo:
es-MX	Spanish (Mexico)	Células CD3 + CD4 +:Concentración numérica:Punto temporal:Sangre:Cuantitativo:
es-ES	Spanish (Spain)	Células CD3+CD4+:Concentración de número:Punto temporal:Sangre:Qn: Synonyms: Cuantitativo
et-EE	Estonian (Estonia)	Rakud.CD3+CD4+:NCnc:Pt:B:Qn: Synonyms: Juhuslik Kvantitatiivne Veri
fr-CA	French (Canada)	Cellules.CD3+CD4+:Concentration numérique:Temps ponctuel:Sang:Quantitatif:
fr-FR	French (France)	CD3+CD4+:Nombre/Volume:Ponctuel:Sang:Numérique:
fr-BE	French (Belgium)	Cellules.CD3+CD4+:Concentration numérique:Temps ponctuel:Sang:Quantitatif:
it-IT	Italian (Italy)	Cellule.CD3+CD4+:NCnc:Pt:Sangue:Qn: Synonyms: Cellule CD3 Cellule CD3+CD4+ Cellule CD3-CD4+ Concentrazione Numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
ko-KR	Korean (Korea, Republic Of)	세포.CD3+CD4+:계수/부피:검사시점:전혈:정량:
nl-NL	Dutch (Netherlands)	cellen.CD3+CD4+:aantal/volume:moment:bloed:kwantitatief:
pt-BR	Portuguese (Brazil)	Células.CD3+CD4+:NCnc:Pt:SgTotal:Qn: Synonyms: ; CD3+CD4+ Cells; CD3 Cells; Cell; Cellularity; Leu-4; Leu4; T3; #; Number concentration; Count/mass; Count; AcS; CT; Acsolute; Acsolutes; Cnt; Point in time; Random; Blood; WB; Whole blood; Quantitative; QNT; Quant; Quan; Leu-3; T-4; Leu3; W3/25; Helper T cells; Inducer T cells; T4; L3T4; CELL MARKERS
ru-RU	Russian (Russian Federation)	Клетки.CD3+CD4+:КолОб:ТчкВрм:Кр:Колич: Synonyms: CD3+CD4+ (T4 хэлперы) клетки Количественный Количество в объеме Кровь Точка во времени;Момент
tr-TR	Turkish (Turkey)	Hücreler.CD3+CD4+:SayKons:Zmlı:Kan:Kant:
uk-UA	Ukrainian (Ukraine)	Клітини.CD3+CD4+:Чисельна Концентрація:МоментЧасу:Кров:Кількісно: Synonyms: #; ABS; absolute; absolutes; Blood; CD3 Cells; CD3+CD4+ Cells; CD3-CD4+; CD4+ T cells; Cell; CELL MARKERS; Cellularity; Cnt; Count; Count/volume; CT; Helper T cells; Inducer T cells; L3T4; Leu3; Leu-3; Leu4; Leu-4; Number concentration; Number Concentration (count/vol); Point in time; QNT; Quan; Quant; Quantitative; Random; T3; T4; T-4; T4 helper/inducer cells; W3/25; WB; Whole blood
zh-CN	Chinese (China)	细胞.CD3+CD4+:计数型浓度:时间点:全血:定量型: Synonyms: CD3+CD4+细胞 CD3-CD4+细胞 CD3细胞 L3T4 Leu3 Leu-3 Leu4;Leu-4;T3 T4 T-4 W3/25 单位体积内的数量或计数;数量型浓度(单位体积);数量或计数型浓度(计数/体积);数量或计数型浓度(单位体积);计数型浓度(单位体积) 发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间细胞含量;细胞性;细胞性质;细胞构成;细胞类细胞标志物血;血液诱导 T 细胞诱导性 T 细胞辅助 T 细胞辅助诱导 T 细胞辅助诱导物 T 细胞

Example Units

Unit	Source
#/mm3	REGENSTRIEF
/uL	Example UCUM Units
10^9/L	eCHN

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