25112-4

Lactate/Creatinine [Molar ratio] in Urine

Active

Part Descriptions

LP15686-6   Lactate
Lactate is produced via the enzyme lactate dehydrogenase(LDH) during fermentation. Elevated urine lactic acid levels are found in patients with multiple carboxylase deficiency, lactic acidosis, dihydrolipoyl dehydrogenase deficiency, PDH complex (E1, E2,E3),oxidative phosphorylation and respiratory chain defects (e.g., MERRF, MELAS, Kearns-Sayre), Crebs acid cycle defects, gluconeogenesis defects (pyruvate carboxylase, fructose-1,6-dihphosphatase, glycogen storage I disorder), short-branched chain acyl-CoA DH deficiency, severe MAD deficiency, VLCAD deficiency, GA I ,other organic acidurias (MMA,PA,IVA), citrullinemia, glycerol kinase deficiency, HMG-CoA lyase deficiency, or EMA aciduria. (Information from: Kumps A, Duez P, Mardens Y. Metabolic, Nutritional, Iatrogenic, and Artifactual Sources of Urinary Organic Acids: A Comprehensive Table. Clinical Chemistry 2002, 48:708-717.) Source: Regenstrief Institute

LP15686-6   Lactate
Lactic acid is chiral and has two optical isomers. One is known as L-(+)-lactic acid or (S)-lactic acid and the other, its mirror image, is D-(−)-lactic acid or (R)-lactic acid. The L isomer is the biologic one. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Lactate

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

Fully-Specified Name

Component

Lactate/Creatinine

Property

SRto

Time

Pt

System

Urine

Scale

Qn

Method

Additional Names

Short Name

Lactate/Creat Ur-sRto

Display Name

Lactate/Creatinine (U) [Molar ratio]

Consumer Name Alpha Get Info

Lactate/Creatinine, Urine

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 2.00

Last Updated

Version 2.73

Order vs. Observation

Both

Common Test Rank Get Info

3835

Member of these Panels

Language Variants Get Info

Related Names

• 2-Hydroxypropanoic acid
• 2-hydroxy-propionate
• 2-hydroxy-propionic acid
• Chemistry
• CR
• Crea
• Creat
• Lact
• Lactic acid
• L-lactate
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Scrto
• Substance concentration ratio
• Substance ratio
• UA
• UCr
• UR
• Urn

Example Units

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