270-9
Gramicidin D [Susceptibility] by Minimum lethal concentration (MLC)
Active
Part Description
LP15763-3 Gramicidin D
Gramicidin is a heterogeneous mixture of six antibiotic compounds, Gramicidins A, B and C, making up 80%, 6%, and 14% respectively, all of which are obtained from the soil bacterial species Bacillus brevis and called collectively Gramicidin D. Gramicidin D are linear pentadecapeptides; that is chains made up of 15 amino acids. This is in contrast to Gramicidin S which is a cyclic peptide chain. Gramicidin is active against Gram-positive bacteria, except for the Gram-positive bacilli, and against select Gram-negative organisms, such as Neisseria bacteria. Its therapeutic use is limited to topical application as it induces hemolysis in lower concentrations than bacteria cell death, thus cannot be administered internally. The exterior epidermis is composed of dead cells, thus applying it to the surface of the skin will not cause harm. It is used primarily as a topical antibiotic and is one of the three constituents of consumer antibiotic Neosporin Ophthalmic Solution. In 1939 the French-American microbiologist René Dubos isolated the substance tyrothricin and later showed that it was composed of two substances, gramicidin (20%) and tyrocidine (80%). These were the first antibiotics to be manufactured commercially.
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Source: Wikipedia, Gramicidin D
Fully-Specified Name
- Component
- Gramicidin D
- Property
- Susc
- Time
- Pt
- System
- Isolate
- Scale
- Qn
- Method
- MLC
Additional Names
- Short Name
- Gramicidin D Islt MLC
- Display Name
- Gramicidin D MLC [Susc]
- Consumer Name Alpha Get Info
- Susceptibility to Gramicidin D
Basic Attributes
- Class
- ABXBACT
- Type
- Laboratory
- First Released
- Version 1.0
- Last Updated
- Version 2.19
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 87927-0 | Bacterial susceptibility panel - Isolate by Minimum lethal concentration (MLC) |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG41059-3 | Gramicidin DSusc| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Gramicidin D: |
| es-AR | Spanish (Argentina) | gramicidina D: |
| es-ES | Spanish (Spain) | Gramicidina D: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Gramicidina D: |
| fr-CA | French (Canada) | Gramicidine D: |
| fr-FR | French (France) | Gramicidine D: |
| fr-BE | French (Belgium) | Gramicidine D: |
| it-IT | Italian (Italy) | Gramicidina D: Synonyms: Concentrazione minima letale (MLC) Punto nel tempo (episodio) Sensibilità (microrganismi) Suscettibilità agli antibiotici |
| ko-KR | Korean (Korea, Republic Of) | 그라미시딘 D: |
| nl-NL | Dutch (Netherlands) | gramicidine D: Synonyms: MLC |
| pt-BR | Portuguese (Brazil) | Gramicidina D: Synonyms: Neosporin; |
| tr-TR | Turkish (Turkey) | Gramisidin D: |
| zh-CN | Chinese (China) | 短杆菌肽 D: Synonyms: Rh; |
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