29810-9

Highlands J virus neutralizing antibody [Titer] in Serum by Neutralization test

Active

Part Descriptions

LP207365-0   Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP28497-3   Highlands J virus
The Highlands J (HJ) virus is a zoonotic alphavirus native to North and South America. It maintains a natural reservoir in the songbird population of freshwater swamps (generally scrub jays and blue jays) and is transmitted by the bite of the female Culiseta melanura mosquito.

Though nearly identical in structure and natural cycle to the Eastern equine encephalitis virus, it is considerably less virulent than its cousin, causing relatively mild symptoms in its primary avian reservoir and only nominally capable of transmission to mammals. A 1995 study conducted in Florida swampland found that 15% of swamp-dwelling jays tested positive for HJ antibodies, all of which were asymptomatic and in apparent good health. Recorded bird deaths from HJ infection are uncommon but not rare, and include several domestic turkeys at a commercial facility and young broiler chickens in an experimental setting.

Transmission to equines or humans via mosquito is also possible, though even more rare.

Despite its negligible virulence in humans, it is often tested for in US domestic mosquito control programs as an indicator of fruitful conditions for other mosquito-borne zoonoses to multiply. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP6416-4   Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name

Highlands J virus Ab.Neut:Titr:Pt:Ser:SemiQn:Neut

Long Common Name

Highlands J virus neutralizing antibody [Titer] in Serum by Neutralization test

Short Name

HJV NAb Titr Ser Nt

Display Name

Highlands J virus neut ab Neut test (S) [Titer]

Consumer Name Alpha Get Info

Highlands J virus neutralizing antibody, Blood

Part Model Get Info

• Component

  Highlands J virus Ab.Neut
  LP430399-8

  • Analyte

    Highlands J virus Ab.Neut
    LP430399-8

    • Component Numerator

      Highlands J virus Ab.Neut
      LP430399-8

      • Component Numerator Core

        Highlands J virus
        LP28497-3

      • Component Numerator Core Suffix

        Ab.Neut
        LP207365-0

    • Component Denominator

      NULL
       

      • Component Denominator Core

        NULL
         

      • Component Denominator Core Suffix

        NULL
         

  • Challenge

    NULL
     

  • Adjustment

    NULL
     

  • Count

    NULL
     

• Property

  Titr
  LP6881-9

• Time

  Pt
  LP6960-1

  • Time Core

    Pt
    LP6960-1

  • Time Modifier

    NULL
     

• System

  Ser
  LP7567-3

  • System Core

    Ser
    LP7567-3

  • Super System

    NULL
     

• Scale

  SemiQn
  LP436123-6

• Method

  Neut
  LP6416-4

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.04

Last Updated

Version 2.75 (MAJ)

Change Reason

Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.;

Order vs. Observation

Both

Language Variants Get Info

Related Names

• ABS
• Aby
• Antby
• Anti
• Antibodies
• Antibody
• Autoantibodies
• Autoantibody
• Conventional virus neutralization test
• cVNT
• Dilution factor
• Dilution Factor (Titer)
• Highland J virus
• HJV
• ID
• Infectious Disease
• InfectiousDisease
• Microbiology
• NAb
• NEUTRALIZATION
• Neutralization test
• NT
• Point in time
• Random
• Serum
• Serum virus neutralization
• SmQn
• SR
• SVN
• Titer
• Titered
• Titre
• Ttr
• Virus neutralization test
• VNT

Example Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=29810-9

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.