31149-8
P53 protein Ag/100 cells in Tissue by Immune stain
Active
Part Description
LP18603-8 P53 protein
The p53 antigen was first discovered in 1979 and recognized as a tumor repressive gene in 1989. It encodes a protein that monitors the cell cycle by suppressing tumor growth and preventing genome mutation. When p53 is defective, abnormal cell proliferation can occur. Mutations in p53 are present in up to 50% of all human tumors. The three major functions of p53 include growth arrest, DNA repair, and apoptosis. P53 halts the growth arrest function of the cell cycle progress which can activate transcription of proteins that repair DNA. There are low levels of p53 in normal cells, but damage to DNA and similar stress signals may precipitate an increase of p53 protein. Cell death is the final course of action to prevent cells containing abnormal DNA from dividing. The concentration of P53 in cells is probably tightly controlled since high concentrations may accelerate aging due to excess apoptosis.
[http://www.bioinformatics.org/p53/introduction.html] Ongoing studies are investigating the utility of the p53 antibody being used as a biomarker for the early detection of lung cancer in high risk asymptomatic patients. PMID: 21733826
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- P53 protein Ag/100 cells
- Property
- NFr
- Time
- Pt
- System
- Tiss
- Scale
- Qn
- Method
- Immune stain
Additional Names
- Short Name
- P53 protein Ag NFr Tiss ImStn
- Display Name
- P53 protein Ag/100 cells Immune stain (Tiss)
- Consumer Name Alpha Get Info
- P53 protein per 100 cells, Tissue
Basic Attributes
- Class
- PATH
- Type
- Laboratory
- First Released
- Version 2.07
- Last Updated
- Version 2.70
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-AR | Spanish (Argentina) | antígeno de proteína p53/100 células: |
| es-ES | Spanish (Spain) | Proteína p53 Antígeno/100 células: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Proteína P53 Ag / 100 células: |
| et-EE | Estonian (Estonia) | P53 valk antigeen/100 raku kohta: Synonyms: Juhuslik Kude Kvantitatiivne |
| fr-CA | French (Canada) | Protéine P53 , Ag/100 cellules: |
| fr-FR | French (France) | Protéine P53 antigène/100 cellules: |
| fr-BE | French (Belgium) | Protéine P53 Ag/100 cellules: Synonyms: Antigène Coloration. Méthode mmunologique |
| it-IT | Italian (Italy) | P53, proteina , Ag/100 cellule: Synonyms: Frazione numerica Patologia Proteina P53 Punto nel tempo (episodio) Tessuto & |
| ko-KR | Korean (Korea, Republic Of) | P53 단백 항원/100 세포: |
| nl-NL | Dutch (Netherlands) | p53-eiwit Ag/100 cellen: Synonyms: antigeen |
| pt-BR | Portuguese (Brazil) | P53 proteína Ag/100 células: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | P53 протеин Аг/100 клеток: Synonyms: Белок Количественный Количество отношение Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | P53 protein Ag/100 hücre: Synonyms: Antijen |
| zh-CN | Chinese (China) | P53 蛋白 抗原/100 个细胞: Synonyms: Ag Oncogene Protein Ag p53 抗癌基因蛋白; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=31149-8
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright