3206-0

Coagulation factor VIII inhibitor [Presence] in Platelet poor plasma by Coagulation assay

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Part Descriptions

LP29023-6 Coagulation factor VIII inhibitor
Factor VIII replacement is the foundational treatment for hemophilia A, and the developement of alloantibodies (known as inhibitors) against the replacement factor is the most important complication causing morbidity in hemophilia patients. Antibodies against factor VIII can be inhibitory or noninhibitory, with inhibitors generally being polycloncal IgG directed against the A2, A3 and C2 domains of the factor VIII molecule. The resulting steric hindrance can block functional epitopes including FIX, phospholipid, or von Willebrand binding sites PMID: 23610614. Source: Regenstrief LOINC

LP14587-7 Factor VIII
Blood-coagulation factor VIII; Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin. Source: National Library of Medicine, MeSH 2006

Fully-Specified Name

Component: Coagulation factor VIII inhibitor
Property: PrThr
Time: Pt
System: PPP
Scale: Ord
Method: Coag

Additional Names

Short Name: Fact VIII Inhib PPP Ql
Display Name: Coagulation factor VIII inhibitor Coag Ql (PPP)
Consumer Name Alpha Get Info: Coagulation Factor VIII Inhibitor, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: COAG
Type: Laboratory
First Released: Version 1.0
Last Updated: Version 2.73
Change Reason: Changed Property from "ACnc" to "Pr" (Presence) to clarify that results (e.g. pos/neg, present/absent) are based on the presence of the inhibitor.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 9942

Member of these Panels

LOINC	Long Common Name
96456-9	Coagulation factor VIII activity and inhibitor panel - Platelet poor plasma by Coagulation assay

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	Gerinnungsfaktor VIII-Inhibitor:Nachweis oder Schwellenwert:Zeitpunkt:Thrombozytenarmes Plasma:Ordinal:Gerinnungstest
es-AR	Spanish (Argentina)	inhibidor de factor de coagulación VIII:concentración arbitraria:punto en el tiempo:plasma desplaquetado:ordinal:coagulación
es-MX	Spanish (Mexico)	Inhibidor del factor VIII de la coagulación:Presencia o umbral:Punto temporal:Plasma pobre en plaquetas:Ordinal:Ensayo de coagulación
es-ES	Spanish (Spain)	Factor de coagulación VIII inhibido:PrThr:Punto temporal:Plasma pobre en plaquetas:Ord:Coagulativo
et-EE	Estonian (Estonia)	VIII faktori inhibiitor:PrThr:Pt:PPP:Ord:Koagulomeetria Synonyms: Järgarvuline Juhuslik Trombotsüütidevaene plasma
fr-FR	French (France)	Facteur VIII inhibiteur:Présence/Seuil:Ponctuel:Plasma pauvre en plaquettes:Qualitatif:Coagulation
fr-BE	French (Belgium)	Inhibiteur du facteur VIII:PrThr:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:Test de coagulation Synonyms: F VIII Test d''Hémostase
fr-CA	French (Canada)	Inhibiteur du facteur VIII:Présence-Seuil:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:Test de coagulation
it-IT	Italian (Italy)	Fattore di coagulazione VIII, inibitore:PrThr:Pt:PPP:Ord:Coag Synonyms: Inibitore del fattore di coagulazione VIII Plasma povero di piastrine Presenza o Soglia Punto nel tempo (episodio) Studio di coagulazione Test di coagulazione
ko-KR	Korean (Korea, Republic Of)	응고 인자 VIII 억제인자:임의농도:검사시점:혈소판제거혈장:순위척도:응고검사
nl-NL	Dutch (Netherlands)	stollingsfactor VIII remmer:aanwezigheid:moment:plaatjesarm plasma:ordinaal:stollingsmethode Synonyms: coagulatiemethode
pl-PL	Polish (Poland)	Inhibitor Czynnika krzepnięcia VIII:granica wykrywalności:punkt w czasie:osocze ubogopłytkowe:półilościowy:test krzepnięcia Synonyms: PPP
pt-BR	Portuguese (Brazil)	Fator de coagulação VIII inibidor:ACnc:Pt:PPPQ:Ord:Coagulação Synonyms: ; Fact VIII; Fact VIII Inhib; VIII:C; Antihemophilic factor; AHF; Antihemophilic globulin; AHG; Factor VIII clotting activity; Thrombocyte cofactor A; Circulating anticoagulant; Arbitrary concentration; Point in time; Random; Platelet poor plasma; Plas; Ql; Ordinal; QL; Qualitative; Qual; Screen; Coagulation assay; Clot; Tilt tube; ClottAcle; Inhibit; F8; FVIII; Factor 8; Fac
ru-RU	Russian (Russian Federation)	Коагуляции фактор VIII ингибитор:PrThr:ТчкВрм:ОПП:Пор:Коаг Synonyms: Анализ факторов свертывания крови;Коагулограмма Обеднённая пластинками плазма;Бедная тромбоцитами плазма Порядковый Точка во времени;Момент
tr-TR	Turkish (Turkey)	Koagülasyon faktörü VIII inhibitörü:MevcEşik:Zmlı:TFkP:Srl:Koag Synonyms: Mevcut
uk-UA	Ukrainian (Ukraine)	Коагуляційний фактор VIII інгібітор:Наявність або Поріг:МоментЧасу:Бідна тромбоцитами плазма:Порядково:Аналіз коагулограми Synonyms: AHF; AHG; Antihemophilic factor; Antihemophilic globulin; Circulating anticoagulant; Clot; Clottable; Coag; Coagulation assay; F8; Fac; Fact; Fact VIII; Fact VIII Inhib; Factor 8; Factor VIII clotting activity; FVIII; Hematology; Heme; Inhib; Inhibit; Ordinal; Plas; Platelet poor plasma; Point in time; PR; QL; Qual; Qualitative; Random; Screen; Thrombocyte cofactor A; Tilt tube; VIII:C
zh-CN	Chinese (China)	凝血因子 VIII 抑制剂:存在情况或阈值:时间点:贫血小板血浆:序数型:凝血功能分析 Synonyms: AHF;AHG;VIII:C;凝血因子 VIII 凝血活性;凝血因子Ⅷ;凝血因子Ⅷ凝血活性;循环型抗凝物;循环型抗凝物质;抗血友病因子;抗血友病因子（Antihemophilic factor，AHF）;抗血友病球蛋白;抗血友病球蛋白（Antihemophilic globulin，AHG）;血小板辅因子 A FVIII 乏血小板血浆;Platelet poor plasma;PPP 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型倾斜试管;倾斜试管法;凝固测定;凝血功能测定;凝血测定;快速凝固试验;快速凝血试验;快速凝集试验凝固;凝固现象;凝血;凝血作用;凝血功能;凝血功能类;凝血类成分;凝血过程凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程凝血因子 VIII（凝血因子Ⅷ、因子 VIII、因子Ⅷ）抑制剂凝血因子Ⅷ;因子 VIII;因子Ⅷ;血液制品 - 凝血因子 VIII;血液制品 - 凝血因子Ⅷ;血液制品 - 因子 VIII;血液制品 - 因子Ⅷ 因子 8 因子 VIII 因素存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）抑制因子抑制物抑制物质时刻;随机;随意;瞬间系数

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