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Term Description

Antiamphiphysin antibodies are associated with various paraneoplastic neurological syndromes and tumors

Part Descriptions

LP30843-4   Amphiphysin
Amphiphysin is a protein associated with the cytoplasmic surface of synaptic vesicles and is encoded by the AMPH gene. Patients with stiff man syndrome and breast cancer can be positive with autoantibodies against the amphiphysin protein. Source: Regenstrief LOINC

LP37039-2   Amphiphysin Ab
Paraneoplastic syndromes (PNS) are diseases associated with remote effects of tumors, of which small-cell lung cancer (SCLC), ovarian cancer, breast cancer, thymoma, Hodgkin lymphoma, and testicular cancer are the most common. Stiff-person syndrome (SPS) is a rare neurological disorder characterized by stiffness of skeletal muscles with superimposed spasms, which can have an idiopathic or paraneoplastic component. First described in women with breast cancer and SPS, amphiphysin antibodies have been reported in patients with diverse paraneoplastic neurological disorders, and cancers. Amphiphysin antibodies are considered diagnosic for paraneoplastic neurologic syndromes and can direct the search for an occult tumor, recurrence of tumor, or second tumor. Source: ARUP Laboratories

LP37039-2   Amphiphysin Ab
Amphiphysin is a brain-enriched protein normally found only within the membrane of synaptic vesicles in neural tissue. Antibodies against amphiphysin (128kDa) are directed against the protein amphiphysin, and their presence plays an important diagnostic role in paraneoplastic syndromes (e.g. Lambert Eaton myasthenia syndrome, encephalomyelitis with rigidity, cerebellar syndrome, sensory neuronopathy, opsoclonus myoclonus ataxia, and Stiff-man syndrome). Paraneoplastic syndromes are autoantibody-mediated neurologic disorders most commonly associated with cancers of the lung, breast, ovaries or lymphatic system. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Amphiphysin Ab:PrThr:Pt:Ser:Ord:
Long Common Name
Amphiphysin Ab [Presence] in Serum
Short Name
Amphiphysin Ab Ser Ql
Display Name
Amphiphysin Ab Ql (S)
Consumer Name Alpha Get Info
Amphiphysin antibody, Blood

Part Model Get Info

  • Component
    Amphiphysin Ab
    LP37039-2
    • Analyte
      Amphiphysin Ab
      LP37039-2
      • Component Numerator
        Amphiphysin Ab
        LP37039-2
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    NULL
     

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.09
Last Updated
Version 2.73 (MIN)
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
6793

Member of these Groups Get Info

LOINC GroupGroup Name
LG13353-4Amphiphysin Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
ar-JOArabic (Jordan)الكشف عن تواجد أضداد الأمففسين في المصل
cs-CZCzech (Czechia)Amfifysin Ab:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:
de-DEGerman (Germany)Amphiphysin Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:
el-GRGreek (Greece)Αμφιφυσίνη Αντίσωμα:PrThr:Pt:Ορός:Ord:
Synonyms: Ord PrThr Pt SERO Αμφιφυσίνη Αντίσωμα Ορός
es-ARSpanish (Argentina)anticuerpo conra anfifisina:concentración arbitraria:punto en el tiempo:suero:ordinal:
es-ESSpanish (Spain)Anfifisina Anticuerpos:PrThr:Punto temporal:Suero:Ord:
es-MXSpanish (Mexico)Amphiphysin Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:
et-EEEstonian (Estonia)Amfifüsiin antikehad:PrThr:Pt:S:Ord:
Synonyms: Järgarvuline Juhuslik Seerum
fr-CAFrench (Canada)Amphiphysine, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:
fr-FRFrench (France)Amphiphysine Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:
fr-BEFrench (Belgium)Amphiphysine Ac:PrThr:Temps ponctuel:Sérum:Ordinal:
Synonyms: Anticorps
it-ITItalian (Italy)Amfifisina Ab:PrThr:Pt:Siero:Ord:
Synonyms: anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
ko-KRKorean (Korea, Republic Of)Amphiphysin Antibody:임의농도:검사시점:혈청:순위척도:
nl-NLDutch (Netherlands)amfifysine As:aanwezigheid:moment:serum:ordinaal:
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)Amfifizyna Ab:granica wykrywalności:punkt w czasie:surowica:uporządkowany:
Synonyms: Przeciwciała do amfifizyny
pt-BRPortuguese (Brazil)Amfifisina Ac:ACnc:Pt:Soro:Ord:
Synonyms: Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RURussian (Russian Federation)Амфифизин Ат:PrThr:ТчкВрм:Сыв:Пор:
Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TRTurkish (Turkey)Amfifizin Ab:MevcEşik:Zmlı:Ser:Srl:
Synonyms: Ak Mevcut
zh-CNChinese (China)双载蛋白 抗体:存在情况或阈值:时间点:血清:序数型:
Synonyms: Ab;自身抗体 Amphiphysin Ab 两亲蛋白;两性蛋白;Amphiphysin（一种位于神经元突触前膜的 128kD 蛋白）;神经元突触囊泡 Amphiphysin;两性蛋白(僵直人综合征伴乳腺癌128kDa 自身抗原);amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen) 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=33422-7