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Part Description

LP31589-2   Erythrocytes.CD59 deficient
Paroxsmal nocturnal hemoglobinuria (PNH) is a condition that causes hemolytic anemia, bone marrow failure, and a proclivity to develop thrombosis. PNH occurs when the PIG-A gene of bone marrow stem cells undergoes mutation. Stems cells develop into erythrocytes (RBCs), white blood cells (WBCs), platelets, and mature cells that contain the PIG-A gene mutation, and as a result, lack a sufficient number of glycosylphosphatidylinositol-anchored protein (GPI-AP). The GPI-APs have various roles, some of which are to help to prevent RBC destruction, fight infection, and promote thrombosis.https://www.hopkinsmedicine.org/kimmel_cancer_center/types_cancer/paroxysmal_nocturnal_hemoglobinuria_PNH.html CD14, 16, 24, and 59 are GPI-linked proteins that are used as markers for the presence of GPI, as is fluorescent aerolysin (FLAER), which binds to GPI-APs. Patients with PNH lack sufficient GPIs and therefore have reduced expression of these cell markers and FLAER compared to patients without PNH. Patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Erythrocytes.CD59 deficient/Cells.235a:NFr:Pt:Bld:Qn:
Long Common Name
Erythrocytes.CD59 deficient/Erythrocytes in Blood
Short Name
RBC CD59 deficient NFr
Display Name
Erythrocytes.CD59 deficient/Cells.235a (Bld)
Consumer Name Alpha Get Info
CD59 deficient red blood cells/Cells.235a, Blood

Part Model Get Info

  • Component
    Erythrocytes.CD59 deficient/Cells.235a
    LP445400-7
    • Analyte
      Erythrocytes.CD59 deficient/Cells.235a
      LP445400-7
      • Component Numerator
        Erythrocytes.CD59 deficient
        LP31589-2
        • Component Numerator Core
          Erythrocytes.CD59 deficient
          LP31589-2
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        Cells.235a
        LP444756-3
        • Component Denominator Core
          Cells.235a
          LP444756-3
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    NFr
    LP6838-9
  • Time
    Pt
    LP6960-1
  • System
    Bld
    LP7057-5
    • System Core
      Bld
      LP7057-5
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.09
Last Updated
Version 2.79 (NAM)
Change Reason
Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component; Previous Releases: Updated denominator from '100 Red blood cells' to '100 Cells.235a+', where CD235a+ is a marker for RBC, and System from 'RBC' to 'Bld' for consistency across cell marker terms.
Order vs. Observation
Observation
Common Test Rank Get Info
6120

Member of these Panels

LOINCLong Common Name
55164-8Paroxysmal nocturnal panel - Blood
90735-2PNH GPI-Linked WBC and RBC Ag Panel - Blood

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Erytrocyty.CD59 deficientní/100 buněk.235a:Početní podíl:Časový bod:Krev:Kvantitativní:
de-DEGerman (Germany)Erythrozyten.CD59 defizient/Zellen.235a:Numerische Fraktion:Zeitpunkt:Blut:Quantitativ:
es-ARSpanish (Argentina)eritrocitos.con deficiencia de CD59/100 células:fracción de un número:punto en el tiempo:eritrocitos:cuantitativo:
es-MXSpanish (Mexico)Eritrocitos Deficiente en CD59 / 100 células.235a:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
es-ESSpanish (Spain)Eritrocitos CD59 deficientes/Células 235a:Fracción numérica:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
fr-CAFrench (Canada)Érythrocytes.CD59 déficients/Cellules.235a:Fraction numérique:Temps ponctuel:Sang:Quantitatif:
fr-FRFrench (France)Érythrocytes CD59-/CD235a:Fraction de nombres:Ponctuel:Sang:Numérique:
it-ITItalian (Italy)Eritrociti.deficit CD59/Cellule.235a:NFr:Pt:Sangue:Qn:
Synonyms: Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) RBC CD59 RBC deficit CD59 Sangue
ko-KRKorean (Korea, Republic Of)적혈구.CD59 결핍/100 세포:숫자분획:검사시점:적혈구:정량:
nl-NLDutch (Netherlands)erytrocyten.CD59-deficiënt/100 cellen.235a:getalsfractie:moment:bloed:kwantitatief:
Synonyms: erytrocyten.CD59 deficient
pl-PLPolish (Poland)Erytrocyty CD59 ujemne/komórki.235a:frakcja liczbowa:punkt w czasie:krew:ilościowy:
Synonyms: CD59 Niedobór CD59
pt-BRPortuguese (Brazil)Eritrócitos.CD59 deficientes/100 eritrócitos:NFr:Pt:Eritroc:Qn:
Synonyms: ; CD59 Def RBC; CD59 RBC; Red blood corpusles; Red blood corpuscle; Erthrocyte; Erythrocyte; Red blood cell; Red cell; Red cells; Discocytes; Red blood cells; RBCS; Cell; Cellularity; Membrane Inhibitor of Reactive Lysis; 1F-5Ag; H19; HRF20; MACIF; MIRL; P-18; Protectin; Gated cells; Fr; Number fraction; Percent; Point in time; Random; Quantitative; QNT; Quant; Quan; CELL MARKERS
zh-CNChinese (China)红细胞.CD59 缺乏型/细胞.235a:计数型分数:时间点:全血:定量型:
Synonyms: 1F-5 抗原;1F-5Ag;H19;HRF20;MACIF;MIRL;P-18;Protectin;保护素;反应性溶血膜抑制物;发现于所有的白细胞和红细胞之上。阵发性睡眠性血红蛋白尿（paroxysmal nocturnal hemoglobinuria，PNH）是由干细胞克隆引起，且伴有红细胞之上的 CD59 下降。;膜反应性溶破抑制物;膜反应性溶解抑制物;膜反应性溶解抑制物（Membrane Inhibitor of Reactive Lysis，MIRL，MIRL/CD59）;膜裂解抑制物 CD59 RBC;CD59 红细胞;RBC.CD59 CD59 缺乏型 RBC;CD59 缺乏型红细胞;RBC.CD59 缺乏型 RBC;RBCS;盘状细胞;红血球;红血细胞;血液制品 - 红细胞 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液

Example Units

UnitSource
%Example UCUM Units
%REGENSTRIEF

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=33662-8