Version 2.74

Part Description

LP31925-8   ACTH stimulation test using IV corticosteroids
The ACTH stimulation test (also called the cosyntropin test, tetracosactide test or Synacthen test) is a medical test usually ordered and interpreted by endocrinologists to assess the functioning of the adrenal glands stress response by measuring the adrenal response to adrenocorticotropic hormone (ACTH). ACTH is a hormone produced in the pituitary gland that stimulates the adrenal glands to release cortisol.

During the test, a small amount of synthetic ACTH is injected, and the amount of cortisol, and sometimes aldosterone, the adrenals produce in response is measured. This test may cause mild to moderate side effects in some individuals.

This test is used to diagnose or exclude primary and secondary adrenal insufficiency, Addison's disease and related conditions. In addition to quantifying adrenal insufficiency, the test can distinguish whether the cause is adrenal (low cortisol and aldosterone production) or pituitary (low ACTH production). The ACTH stimulation test is recognized as the gold standard assay of adrenal insufficiency, although this test is primarily used to determine the presence of Addison's disease and pituitary impairment. If the test does not show Addison's, the test interpreter may see it as showing the adrenal glands are working, not recognizing any degree of adrenal insufficiency between Addison's (the worst degree of adrenal insufficiency) and healthy adrenal function.[citation needed] The test is extremely sensitive (97% at 95% specificity) to primary adrenal insufficiency, but less so to secondary adrenal insufficiency (57-61% at 95% specificity); while secondary adrenal insufficiency may thus be dismissed by some interpreters on the basis of the test, additional testing may be called for if probability of secondary adrenal insufficiency is particularly high.

Adrenal insufficiency is a potentially life-threatening condition. Treatment should be initiated as soon as the diagnosis is confirmed, or sooner if the patient presents in apparent adrenal crisis Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, Wikipedia

Panel Hierarchy

Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
34542-1 ACTH stimulation test using IV corticosteroids in Serum or Plasma
Indent2143-6 Cortisol [Mass/volume] in Serum or Plasma R ug/dL
Indent1417-5 Cortisol [Mass/volume] in Serum or Plasma --30 minutes post 250 ug corticotropin IV rapid R ug/dL
Indent1402-7 Cortisol [Mass/volume] in Serum or Plasma --1 hour post 250 ug corticotropin IV rapid O ug/dL

Fully-Specified Name

ACTH stimulation test using IV corticosteroids

Additional Names

Short Name
ACTH Stim IV Pnl SerPl
Display Name
ACTH stimulation test using IV corticosteroids
Consumer Name Alpha Get Info
ACTH stimulation test using intravenous corticosteroids, Blood

Basic Attributes

First Released
Version 2.10
Last Updated
Version 2.73
Order vs. Observation
Common Test Rank Get Info
Panel Type

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) prueba de estimulación de ACTH^prueba analítica de 250 ug de corticotrofina endovenosa:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-ES Spanish (Spain) Prueba de estimulación de ACTH con corticosteroides intravenosos:Propiedades mixtas (sólo paneles):Punto temporal:Suero o Plasma:-:
es-MX Spanish (Mexico) Prueba de estimulación de ACTH con corticosteroides intravenosos:-:Punto temporal:Suero o Plasma:-:
fr-CA French (Canada) Test de stimulation par ACTH utilisant des corticostéroïdes intraveineuse:-:Temps ponctuel:Sérum/Plasma:-:
fr-FR French (France) Acth test de stimulation avec corticostéroïdes IV:-:Ponctuel:Sérum/Plasma:-:
fr-BE French (Belgium) Essai de stimulation de l'ACTH^250 ug corticostéroides voie intraveineuse:-:Temps ponctuel:Sérum/Plasma:-:
Synonyms: Simulation de l''ACTH.250µg corticostéroïdes intraveineuse
it-IT Italian (Italy) ACTH, test di provocazione con corticosteroidi EV:-:Pt:Siero/Plasma:-:
Synonyms: Plasma Punto nel tempo (episodio) Set di prescrizione per provocazione Siero Siero o Plasma Test di provocazione Test di stimolo dell''ACTH con corticosteroidi EV;
nl-NL Dutch (Netherlands) ACTH-stimulatie-test met behulp van IV corticosteroïden:-:moment:serum of plasma:-:
Synonyms: ACTH stimulatie test met behulp van IV corticosteroiden
pt-BR Portuguese (Brazil) Teste de estímulo com ACTH em uso de corticosteróides EV:-:Pt:Sor/Plas:-:
Synonyms: ; ACTH Stim IV Pnl; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Corticoster; Corticosteroid; PANEL.CHALLENGE; PANEL.CHALLENGE; CHEMISTRY.CHALLENGE TESTING
ru-RU Russian (Russian Federation) АКТГ стимуляция тест с применением ВВ кортикостероидов:-:ТчкВрм:Сыв/Плаз:-:
Synonyms: Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
zh-CN Chinese (China) ACTH刺激试验^静脉注射250 ug促肾上腺皮质激素组套:-:时间点:血清/血浆:-:
Synonyms: ACTH刺激试验^静脉注射250 ug促肾上腺皮质激素组套(组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目);ACTH刺激试验^250 ug 促肾上腺皮质激素 IV 医嘱组;ACTH刺激试验^250 ug 促肾上腺皮质激素 静注 医嘱组;ACTH刺激试验^250 ug 促肾上腺皮质激素 静脉注射 医嘱组;ACTH刺激试验^250微克 促肾上腺皮质激素 IV 医嘱组;ACTH刺激试验^250微克 促肾上腺皮质激素 静注 医嘱组;ACTH刺激试验^250微克 促肾上腺皮质激素 静脉注射 医嘱组;A 促皮激素刺激试验 促肾上腺皮质激素刺激试验 兴奋 刺激作用 医嘱套餐 医嘱套餐类 医嘱套餐组 医嘱组 医嘱组合 医嘱组合类 医嘱组套 医嘱组套类 医嘱组类 多重;多重型;多重标尺类型;多重精度类型 套餐 套餐医嘱 套餐医嘱组 套餐医嘱组类 实验室医嘱套餐 实验室医嘱套餐类 实验室医嘱组 实验室医嘱组合类 实验室医嘱组套 实验室医嘱组套类 实验室套餐医嘱组 实验室套餐医嘱组类 实验室检验项目医嘱组合类 实验室检验项目组合类 时刻;随机;随意;瞬间 检验医嘱组合类 检验项目医嘱组合类 检验项目组合类 皮质甾 皮质甾类 皮质类固醇 皮质类固醇激素 皮质类甾醇 皮质类甾醇类 组 组合 组合医嘱 组合类 组套 组套(组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目).刺激耐受类检测 血清或血浆

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